Näytä suppeat kuvailutiedot

dc.contributor.authorZandi, Linda
dc.contributor.authorMakungu, Marco
dc.contributor.authorMunissi, Joan J. E.
dc.contributor.authorDuffy, Sandra
dc.contributor.authorPuttreddy, Rakesh
dc.contributor.authorvon der Heiden, Daniel
dc.contributor.authorRissanen, Kari
dc.contributor.authorAvery, Vicky M.
dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorErdélyi, Máté
dc.date.accessioned2020-09-01T09:42:01Z
dc.date.available2020-09-01T09:42:01Z
dc.date.issued2020
dc.identifier.citationZandi, L., Makungu, M., Munissi, J. J. E., Duffy, S., Puttreddy, R., von der Heiden, D., Rissanen, K., Avery, V. M., Nyandoro, S. S., & Erdélyi, M. (2020). Secoiridoids and Iridoids from Morinda asteroscepa. <i>Journal of Natural Products</i>, <i>83</i>(9), 2641-2646. <a href="https://doi.org/10.1021/acs.jnatprod.0c00447" target="_blank">https://doi.org/10.1021/acs.jnatprod.0c00447</a>
dc.identifier.otherCONVID_41836607
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/71578
dc.description.abstractThe new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofseriesJournal of Natural Products
dc.rightsCC BY 4.0
dc.subject.otherchemical structure
dc.subject.otherorganic compounds
dc.subject.otheralkyls
dc.subject.othernuclear magnetic resonance spectroscopy
dc.titleSecoiridoids and Iridoids from Morinda asteroscepa
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202009015706
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineSoveltavan kemian yksikköfi
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineThe Unit of Applied Chemistryen
dc.contributor.oppiaineOrganic Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2641-2646
dc.relation.issn0163-3864
dc.relation.numberinseries9
dc.relation.volume83
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 American Chemical Society and American Society of Pharmacognosy
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber298817
dc.subject.ysoorgaaniset yhdisteet
dc.subject.ysoantimikrobiset yhdisteet
dc.subject.ysoluonnonaineet
dc.subject.ysomatarakasvit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3841
jyx.subject.urihttp://www.yso.fi/onto/yso/p21949
jyx.subject.urihttp://www.yso.fi/onto/yso/p6956
jyx.subject.urihttp://www.yso.fi/onto/yso/p12221
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1021/acs.jnatprod.0c00447
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramPostdoctoral Researcher, AoFen
jyx.fundingprogramTutkijatohtori, SAfi
jyx.fundinginformationThe Swedish Research Council (Swedish Research Links 2012-6074 and 2016-05857), the Academy of Finland (RP, grant no. 298817), and the Australian Research Council (VMA, grant LP120200557) are gratefully acknowledged for financial support. S.S.N. thanks the Swedish Institute for a postdoctoral research award (00045/2014). J.J.E.M. is grateful to the International Foundation for Sciences’ (IFS) financial support. Authors acknowledge Mr. Frank M. Mbago, a senior taxonomist and curator at the Herbarium of the Department of Botany, University of Dar es Salaam, for locating and identifying the plant species in the reported investigation. The Swedish NMR Centre is acknowledged for access to an 800 MHz spectrometer. The project made use of the NMR Uppsala infrastructure, which is funded by the Department of Chemistry–BMC and the Disciplinary Domain of Medicine and Pharmacy.
dc.type.okmA1


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