Field-Grown and In Vitro Propagated Round-Leaved Sundew (Drosera rotundifolia L.) Show Differences in Metabolic Profiles and Biological Activities
Tienaho, J., Reshamwala, D., Karonen, M., Silvan, N., Korpela, L., Marjomäki, V., & Sarjala, T. (2021). Field-Grown and In Vitro Propagated Round-Leaved Sundew (Drosera rotundifolia L.) Show Differences in Metabolic Profiles and Biological Activities. Molecules, 26(12), Article 3581. https://doi.org/10.3390/molecules26123581
© 2021 the Authors
Drosera rotundifolia L. is a carnivorous plant used in traditional medicine for its therapeutic properties. Because of its small size, its collection in nature is laborious and different cultivation methods have been studied to ensure availability. However, only a few studies exist where the lab-grown sundew tissue and field-grown sundew would have been compared in their functionality or metabolic profiles. In this study, the antioxidant and antiviral activities of lab-grown and field-grown sundew extracts and their metabolic profiles are examined. The effect of drying methods on the chromatographic profile of the extracts is also shown. Antioxidant activity was significantly higher (5–6 times) in field-grown sundew but antiviral activity against enterovirus strains coxsackievirus A9 and B3 was similar in higher extract concentrations (cell viability ca. 90%). Metabolic profiles showed that the majority of the identified compounds were the same but field-grown sundew contained higher numbers and amounts of secondary metabolites. Freeze-drying, herbal dryer, and oven or room temperature drying of the extract significantly decreased the metabolite content from −72% up to −100%. Freezing was the best option to preserve the metabolic composition of the sundew extract. In conclusion, when accurately handled, the lab-grown sundew possesses promising antiviral properties, but the secondary metabolite content needs to be higher for it to be considered as a good alternative for the field-grown sundew. ...
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Additional information about fundingThis research was funded by The European Agricultural Fund for Rural Development: Liaison Entre Actions de Développement de l’Économie Rurale (LEADER) for project Innoherb—new business opportunities from mire herbs in Pohjois-Satakunta, Western Finland (https://www.luke.fi/en/projektit/innoherb/, accesses on 18 April 2021). In addition, antiviral activities were examined under the Business Finland corona-co-creation funded project ‘Antiviral fibers—pilot with extracts from Finnish forests [grant: 40699/31/2020]. This study was also funded by Luke’s strategic research funding and J. Tienaho received a personal grant from ‘Suoviljelysyhdistys ry’. ...
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