Secoiridoids and Iridoids from Morinda asteroscepa
Zandi, L., Makungu, M., Munissi, J. J. E., Duffy, S., Puttreddy, R., von der Heiden, D., Rissanen, K., Avery, V. M., Nyandoro, S. S., & Erdélyi, M. (2020). Secoiridoids and Iridoids from Morinda asteroscepa. Journal of Natural Products, 83(9), 2641-2646. https://doi.org/10.1021/acs.jnatprod.0c00447
Published inJournal of Natural Products
© 2020 American Chemical Society and American Society of Pharmacognosy
The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).
PublisherAmerican Chemical Society (ACS)
Publication in research information system
MetadataShow full item record
Related funder(s)Academy of Finland
Funding program(s)Postdoctoral Researcher, AoF
Additional information about fundingThe Swedish Research Council (Swedish Research Links 2012-6074 and 2016-05857), the Academy of Finland (RP, grant no. 298817), and the Australian Research Council (VMA, grant LP120200557) are gratefully acknowledged for financial support. S.S.N. thanks the Swedish Institute for a postdoctoral research award (00045/2014). J.J.E.M. is grateful to the International Foundation for Sciences’ (IFS) financial support. Authors acknowledge Mr. Frank M. Mbago, a senior taxonomist and curator at the Herbarium of the Department of Botany, University of Dar es Salaam, for locating and identifying the plant species in the reported investigation. The Swedish NMR Centre is acknowledged for access to an 800 MHz spectrometer. The project made use of the NMR Uppsala infrastructure, which is funded by the Department of Chemistry–BMC and the Disciplinary Domain of Medicine and Pharmacy. ...
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