Prenylated Flavonoids from the Roots of Tephrosia rhodesica
| dc.contributor.author | Atilaw, Yoseph | |
| dc.contributor.author | Muiva-Mutisya, Lois | |
| dc.contributor.author | Bogaerts, Jonathan | |
| dc.contributor.author | Duffy, Sandra | |
| dc.contributor.author | Valkonen, Arto | |
| dc.contributor.author | Heydenreich, Matthias | |
| dc.contributor.author | Avery, Vicky M. | |
| dc.contributor.author | Rissanen, Kari | |
| dc.contributor.author | Erdélyi, Máté | |
| dc.contributor.author | Yenesew, Abiy | |
| dc.date.accessioned | 2020-08-17T13:17:16Z | |
| dc.date.available | 2020-08-17T13:17:16Z | |
| dc.date.issued | 2020 | |
| dc.identifier.citation | Atilaw, Y., Muiva-Mutisya, L., Bogaerts, J., Duffy, S., Valkonen, A., Heydenreich, M., Avery, V. M., Rissanen, K., Erdélyi, M., & Yenesew, A. (2020). Prenylated Flavonoids from the Roots of Tephrosia rhodesica. <i>Journal of Natural Products</i>, <i>83</i>(8), 2390-2398. <a href="https://doi.org/10.1021/acs.jnatprod.0c00245" target="_blank">https://doi.org/10.1021/acs.jnatprod.0c00245</a> | |
| dc.identifier.other | CONVID_41741658 | |
| dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/71417 | |
| dc.description.abstract | Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. | en |
| dc.format.mimetype | application/pdf | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | American Chemical Society (ACS) | |
| dc.relation.ispartofseries | Journal of Natural Products | |
| dc.rights | CC BY 4.0 | |
| dc.subject.other | metabolism | |
| dc.subject.other | carbon | |
| dc.subject.other | circular dichroism spectroscopy | |
| dc.subject.other | molecular structure | |
| dc.subject.other | nuclear magnetic resonance spectroscopy | |
| dc.title | Prenylated Flavonoids from the Roots of Tephrosia rhodesica | |
| dc.type | research article | |
| dc.identifier.urn | URN:NBN:fi:jyu-202008175553 | |
| dc.contributor.laitos | Kemian laitos | fi |
| dc.contributor.laitos | Department of Chemistry | en |
| dc.contributor.oppiaine | Orgaaninen kemia | fi |
| dc.contributor.oppiaine | Organic Chemistry | en |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.description.reviewstatus | peerReviewed | |
| dc.format.pagerange | 2390-2398 | |
| dc.relation.issn | 0163-3864 | |
| dc.relation.numberinseries | 8 | |
| dc.relation.volume | 83 | |
| dc.type.version | publishedVersion | |
| dc.rights.copyright | © 2020 American Chemical Society and American Society of Pharmacognosy | |
| dc.rights.accesslevel | openAccess | fi |
| dc.type.publication | article | |
| dc.relation.grantnumber | 314343 | |
| dc.subject.yso | luonnonaineet | |
| dc.subject.yso | antimikrobiset yhdisteet | |
| dc.subject.yso | hernekasvit | |
| dc.subject.yso | flavonoidit | |
| dc.format.content | fulltext | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p6956 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p21949 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p21188 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p6771 | |
| dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
| dc.relation.doi | 10.1021/acs.jnatprod.0c00245 | |
| dc.relation.funder | Research Council of Finland | en |
| dc.relation.funder | Suomen Akatemia | fi |
| jyx.fundingprogram | Research costs of Academy Research Fellow, AoF | en |
| jyx.fundingprogram | Akatemiatutkijan tutkimuskulut, SA | fi |
| jyx.fundinginformation | Y.A. is grateful to the German Academic Exchange Services (DAAD) for a scholarship that was offered through the Natural Products Research Network for Eastern and Central Africa (NAPRECA). The Swedish Research Council (Swedish Research Links, NOs. 2012-6124 and 2019-03715), the International Science Program (ISP Sweden, Grant No. KEN-02), and the Australian Research Council (Grant No. LP120200557 to V.M.A.) are gratefully acknowledged for financial support. We thank the Australian Red Cross Blood Service for the provision of human blood. Jonathan Bogaerts thanks the Research foundation Flanders (FWO-Vlaanderen) for the appointment of a predoctoral scholarship (No. 1198318N) and acknowledges the Flemisch Supercomputing Centre (VSC) for providing computational resources and support. The Academy of Finland (Grant No. 314343 to A.V.) is also gratefully acknowledged for funding. The Swedish NMR Centre is acknowledged for access to an 800 MHz spectrometer. | |
| dc.type.okm | A1 |
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