Prenylated Flavonoids from the Roots of Tephrosia rhodesica
Atilaw, Y., Muiva-Mutisya, L., Bogaerts, J., Duffy, S., Valkonen, A., Heydenreich, M., Avery, V. M., Rissanen, K., Erdélyi, M., & Yenesew, A. (2020). Prenylated Flavonoids from the Roots of Tephrosia rhodesica. Journal of Natural Products, 83(8), 2390-2398. https://doi.org/10.1021/acs.jnatprod.0c00245
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Journal of Natural ProductsDate
2020Copyright
© 2020 American Chemical Society and American Society of Pharmacognosy
Five new compounds—rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)—along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
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American Chemical Society (ACS)ISSN Search the Publication Forum
0163-3864Keywords
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Research costs of Academy Research Fellow, AoFAdditional information about funding
Y.A. is grateful to the German Academic Exchange Services (DAAD) for a scholarship that was offered through the Natural Products Research Network for Eastern and Central Africa (NAPRECA). The Swedish Research Council (Swedish Research Links, NOs. 2012-6124 and 2019-03715), the International Science Program (ISP Sweden, Grant No. KEN-02), and the Australian Research Council (Grant No. LP120200557 ...
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