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dc.contributor.authorKesäniemi, Jenni
dc.contributor.authorLavrinienko, Anton
dc.contributor.authorTukalenko, Eugene
dc.contributor.authorMoutinho, Ana Filipa
dc.contributor.authorMappes, Tapio
dc.contributor.authorMøller, Anders Pape
dc.contributor.authorMousseau, Timothy A.
dc.contributor.authorWatts, Phillip C.
dc.date.accessioned2020-02-04T13:14:08Z
dc.date.available2020-02-04T13:14:08Z
dc.date.issued2020
dc.identifier.citationKesäniemi, J., Lavrinienko, A., Tukalenko, E., Moutinho, A. F., Mappes, T., Møller, A. P., Mousseau, T. A., & Watts, P. C. (2020). Exposure to environmental radionuclides alters mitochondrial DNA maintenance in a wild rodent. <i>Evolutionary Ecology</i>, <i>34</i>(2), 163-174. <a href="https://doi.org/10.1007/s10682-019-10028-x" target="_blank">https://doi.org/10.1007/s10682-019-10028-x</a>
dc.identifier.otherCONVID_34510151
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/67733
dc.description.abstractMitochondria are sensitive to oxidative stress, including that derived from ionizing radiation. To quantify the effects of exposure to environmental radionuclides on mitochondrial DNA (mtDNA) dynamics in wildlife, bank voles (Myodes glareolus) were collected from the chernobyl exclusion zone (CEZ), where animals are exposed to elevated levels of radionuclides, and from uncontaminated areas within the CEZ and elsewhere in Ukraine. Brains of bank voles from outside the CEZ were characterized by low mtDNA copy number and low mtDNA damage; by contrast, bank voles within the CEZ had high mtDNA copy number and high mtDNA damage, consistent with putative damaging effects of elevated radiation and a compensatory response to maintain sufficient functioning mitochondria. In animals outside the CEZ, the expression levels of PGC-1α gene and mtDNA copy number were positively correlated as expected from this gene’s prominent role in mitochondrial biogenesis; this PGC-1α-mtDNA copy number association is absent in samples from the CEZ. Our data imply that exposure to radionuclides is associated with altered mitochondrial dynamics, evident in level of mtDNA and mtDNA damage and the level of activity in mitochondrial synthesis.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesEvolutionary Ecology
dc.rightsCC BY 4.0
dc.subject.otherDNA damage
dc.subject.otherionizing radiation
dc.subject.othermitochondria
dc.subject.otherMyodes glareolus
dc.titleExposure to environmental radionuclides alters mitochondrial DNA maintenance in a wild rodent
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202002041986
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange163-174
dc.relation.issn0269-7653
dc.relation.numberinseries2
dc.relation.volume34
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2020
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber268670
dc.subject.ysomitokondrio-DNA
dc.subject.ysoionisoiva säteily
dc.subject.ysomitokondriot
dc.subject.ysometsämyyrä
dc.subject.ysoDNA
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p20961
jyx.subject.urihttp://www.yso.fi/onto/yso/p459
jyx.subject.urihttp://www.yso.fi/onto/yso/p21158
jyx.subject.urihttp://www.yso.fi/onto/yso/p513
jyx.subject.urihttp://www.yso.fi/onto/yso/p7690
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s10682-019-10028-x
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundinginformationOpen access funding provided by University of Oulu including Oulu University Hospital. We acknowledge Gennadi Milinevsky, Igor Chizhevsky, Andrii Simon, Serhii Kirieiev, Anatoly Nosovsky and Maksym Ivanenko for logistic support and help in organizing fieldwork in Ukraine. PCW and TM were funded by Academy of Finland (Project Numbers 287153 and 268670). TAM and APM were supported by awards from the Samuel Freeman Charitable Trust and the American Council of Learned Societies.
dc.type.okmA1


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