Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length
Kesäniemi, J., Lavrinienko, A., Tukalenko, E., Boratyński, Z., Kivisaari, K., Mappes, T., Milinevsky, G., Møller, A. P., Mousseau, T. A., & Watts, P. (2019). Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length. Scientific Reports, 9, Article 850. https://doi.org/10.1038/s41598-018-37164-8
Published inScientific Reports
© The Authors, 2019
Telomeres, the protective structures at the ends of chromosomes, can be shortened when individuals are exposed to stress. In some species, the enzyme telomerase is expressed in adult somatic tissues, and potentially protects or lengthens telomeres. Telomeres can be damaged by ionizing radiation and oxidative stress, although the effect of chronic exposure to elevated levels of radiation on telomere maintenance is unknown for natural populations. We quantified telomerase expression and telomere length (TL) in different tissues of the bank vole Myodes glareolus, collected from the Chernobyl Exclusion Zone, an environment heterogeneously contaminated with radionuclides, and from uncontaminated control sites elsewhere in Ukraine. Inhabiting the Chernobyl Exclusion Zone was associated with reduced TL in the liver and testis, and upregulation of telomerase in brain and liver. Thus upregulation of telomerase does not appear to associate with longer telomeres but may reflect protective functions other than telomere maintenance or an attempt to maintain shorter telomeres in a stressful environment. Tissue specific differences in the rate of telomere attrition and apparent radiosensitivity weaken the intra-individual correlation in telomere length among tissues in voles exposed to radionuclides. Our data show that ionizing radiation alters telomere homeostasis in wild animal populations in tissue specific ways. ...
PublisherNature Publishing Group
Publication in research information system
MetadataShow full item record
Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF
Additional information about fundingPCW and TM are funded by Academy of Finland (project numbers 287153 and 268670 respectively). TAM and APM were supported by the Samuel Freeman Charitable Trust, the CNRS, and the University of South Carolina. ZB is supported by the Portuguese Foundation for Science and Technology (SFRH/BPD/84822/2012). KK is supported by the Emil Aaltonen Foundation (Grant No. 160107).
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Lisämateriaali artikkeliin "Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent". Kivisaari, Kati; Watts, Phillip; Lavrinienko, Anton; Mappes, Tapio; Kesäniemi, Jenni; Jernfors, Toni; Kiljunen, MikkoElectronic material for Kesäniemi J, Jernfors T, Lavrinienko A, Kivisaari K, Kiljunen M, Mappes T & Watts PC. 2019. Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a ...
Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides Jernfors, Toni; Danforth, John; Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Fajkus, Jiří; Dvořáčková, Martina; Mappes, Tapio; Watts, Phillip C. (John Wiley & Sons, 2021)Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from ...
Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Moutinho, Ana Filipa; Mappes, Tapio; Møller, Anders Pape; Mousseau, Timothy A.; Watts, Phillip C. (Springer, 2020)Mitochondria are sensitive to oxidative stress, including that derived from ionizing radiation. To quantify the effects of exposure to environmental radionuclides on mitochondrial DNA (mtDNA) dynamics in wildlife, bank ...
Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent Kesäniemi, Jenni; Jernfors, Toni; Lavrinienko, Anton; Kivisaari, Kati; Kiljunen, Mikko; Mappes, Tapio; Watts, Phillip C. (John Wiley & Sons, 2019)Wildlife inhabiting environments contaminated by radionuclides face putative detrimental effects of exposure to ionizing radiation, with biomarkers such as an increase in DNA damage and/or oxidative stress commonly associated ...
The effect of chronic low-dose environmental radiation on organ mass of bank voles in the Chernobyl Exclusion Zone Kivisaari, Kati; Boratyński, Zbyszek; Lavrinienko, Anton; Kesäniemi, Jenni; Lehmann, Philipp; Mappes, Tapio (Taylor & Francis, 2020)Purpose: Animals are exposed to environmental ionizing radiation (IR) externally through proximity to contaminated soil and internally through ingestion and inhalation of radionuclides. Internal organs can respond to ...