Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent
Kesäniemi, J., Jernfors, T., Lavrinienko, A., Kivisaari, K., Kiljunen, M., Mappes, T., & Watts, P. C. (2019). Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent. Molecular Ecology, 28(20), 4620-4635. https://doi.org/10.1111/mec.15241
Published inMolecular Ecology
DisciplineEkologia ja evoluutiobiologiaAkvaattiset tieteetEcology and Evolutionary BiologyAquatic Sciences
© 2019 John Wiley & Sons Ltd
Wildlife inhabiting environments contaminated by radionuclides face putative detrimental effects of exposure to ionizing radiation, with biomarkers such as an increase in DNA damage and/or oxidative stress commonly associated with radiation exposure. To examine the effects of exposure to radiation on gene expression in wildlife, we conducted a de novo RNA sequencing study of liver and spleen tissues from a rodent, the bank vole Myodes glareolus. Bank voles were collected from the Chernobyl Exclusion Zone (CEZ), where animals were exposed to elevated levels of radionuclides, and from uncontaminated areas near Kyiv, Ukraine. Counter to expectations, we did not observe a strong DNA damage response in animals exposed to radionuclides, although some signs of oxidative stress were identified. Rather, exposure to environmental radionuclides was associated with upregulation of genes involved in lipid metabolism and fatty acid oxidation in the livers – an apparent shift in energy metabolism. Moreover, using stable isotope analysis, we identified that fur from bank voles inhabiting the CEZ had enriched isotope values of nitrogen: such an increase is consistent with increased fatty acid metabolism, but also could arise from a difference in diet or habitat between the CEZ and elsewhere. In livers and spleens, voles inhabiting the CEZ were characterized by immunosuppression, such as impaired antigen processing, and activation of leukocytes involved in inflammatory responses. In conclusion, exposure to low dose environmental radiation impacts pathways associated with immunity and lipid metabolism, potentially as a stress‐induced coping mechanism. ...
PublisherJohn Wiley & Sons
Dataset(s) related to the publicationhttps://doi.org/10.5061/dryad.j3c6r69
Publication in research information system
MetadataShow full item record
Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF
Additional information about fundingPW and TM were funded by Academy of Finland (project numbers 287153 and 268670, respectively).
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Lisämateriaali artikkeliin "Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent". Kivisaari, Kati; Watts, Phillip; Lavrinienko, Anton; Mappes, Tapio; Kesäniemi, Jenni; Jernfors, Toni; Kiljunen, MikkoElectronic material for Kesäniemi J, Jernfors T, Lavrinienko A, Kivisaari K, Kiljunen M, Mappes T & Watts PC. 2019. Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a ...
Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Moutinho, Ana Filipa; Mappes, Tapio; Møller, Anders Pape; Mousseau, Timothy A.; Watts, Phillip C. (Springer, 2020)Mitochondria are sensitive to oxidative stress, including that derived from ionizing radiation. To quantify the effects of exposure to environmental radionuclides on mitochondrial DNA (mtDNA) dynamics in wildlife, bank ...
Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides Jernfors, Toni; Danforth, John; Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Fajkus, Jiří; Dvořáčková, Martina; Mappes, Tapio; Watts, Phillip C. (John Wiley & Sons, 2021)Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from ...
Jernfors, Toni (2022)Organisms defend against external disturbances using various metabolic and genomic methods. Organisms experience stress when the disturbances grow severe enough to debilitate survival or reproduction. Low dose ionising ...
Infection Load and Prevalence of Novel Viruses Identified from the Bank Vole Do Not Associate with Exposure to Environmental Radioactivity Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Mappes, Tapio; Watts, Phillip C.; Jurvansuu, Jaana (MDPI AG, 2020)Bank voles (Myodes glareolus) are host to many zoonotic viruses. As bank voles inhabiting areas contaminated by radionuclides show signs of immunosuppression, resistance to apoptosis, and elevated DNA repair activity, we ...