Exposure to environmental radionuclides alters mitochondrial DNA maintenance in a wild rodent
Kesäniemi, J., Lavrinienko, A., Tukalenko, E., Moutinho, A. F., Mappes, T., Møller, A. P., Mousseau, T. A., & Watts, P. C. (2020). Exposure to environmental radionuclides alters mitochondrial DNA maintenance in a wild rodent. Evolutionary Ecology, 34(2), 163-174. https://doi.org/10.1007/s10682-019-10028-x
Julkaistu sarjassa
Evolutionary EcologyTekijät
Päivämäärä
2020Tekijänoikeudet
© The Author(s) 2020
Mitochondria are sensitive to oxidative stress, including that derived from ionizing radiation. To quantify the effects of exposure to environmental radionuclides on mitochondrial DNA (mtDNA) dynamics in wildlife, bank voles (Myodes glareolus) were collected from the chernobyl exclusion zone (CEZ), where animals are exposed to elevated levels of radionuclides, and from uncontaminated areas within the CEZ and elsewhere in Ukraine. Brains of bank voles from outside the CEZ were characterized by low mtDNA copy number and low mtDNA damage; by contrast, bank voles within the CEZ had high mtDNA copy number and high mtDNA damage, consistent with putative damaging effects of elevated radiation and a compensatory response to maintain sufficient functioning mitochondria. In animals outside the CEZ, the expression levels of PGC-1α gene and mtDNA copy number were positively correlated as expected from this gene’s prominent role in mitochondrial biogenesis; this PGC-1α-mtDNA copy number association is absent in samples from the CEZ. Our data imply that exposure to radionuclides is associated with altered mitochondrial dynamics, evident in level of mtDNA and mtDNA damage and the level of activity in mitochondrial synthesis.
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SpringerISSN Hae Julkaisufoorumista
0269-7653Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/34510151
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Suomen AkatemiaRahoitusohjelmat(t)
Akatemiahanke, SALisätietoja rahoituksesta
Open access funding provided by University of Oulu including Oulu University Hospital. We acknowledge Gennadi Milinevsky, Igor Chizhevsky, Andrii Simon, Serhii Kirieiev, Anatoly Nosovsky and Maksym Ivanenko for logistic support and help in organizing fieldwork in Ukraine. PCW and TM were funded by Academy of Finland (Project Numbers 287153 and 268670). TAM and APM were supported by awards from the Samuel Freeman Charitable Trust and the American Council of Learned Societies.![showless](/themes/JYX2//images/showless.png)
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Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides
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Lisämateriaali artikkeliin "Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent".
Kivisaari, Kati; Watts, Phillip; Lavrinienko, Anton; Mappes, Tapio; Kesäniemi, Jenni; Jernfors, Toni; Kiljunen, Mikko (DRYAD, 2022)Electronic material for Kesäniemi J, Jernfors T, Lavrinienko A, Kivisaari K, Kiljunen M, Mappes T & Watts PC. 2019. Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a ... -
Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length
Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Boratyński, Zbyszek; Kivisaari, Kati; Mappes, Tapio; Milinevsky, Gennadi; Møller, Anders Pape; Mousseau, Timothy A.; Watts, Phillip (Nature Publishing Group, 2019)Telomeres, the protective structures at the ends of chromosomes, can be shortened when individuals are exposed to stress. In some species, the enzyme telomerase is expressed in adult somatic tissues, and potentially protects ... -
Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent
Kesäniemi, Jenni; Jernfors, Toni; Lavrinienko, Anton; Kivisaari, Kati; Kiljunen, Mikko; Mappes, Tapio; Watts, Phillip C. (John Wiley & Sons, 2019)Wildlife inhabiting environments contaminated by radionuclides face putative detrimental effects of exposure to ionizing radiation, with biomarkers such as an increase in DNA damage and/or oxidative stress commonly associated ... -
Analysis of heteroplasmy in bank voles inhabiting the Chernobyl exclusion zone : A commentary on Baker et al. (2017) "Elevated mitochondrial genome variation after 50 generations of radiation exposure in a wild rodent."
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