Exposure to environmental radionuclides alters mitochondrial DNA maintenance in a wild rodent
Kesäniemi, J., Lavrinienko, A., Tukalenko, E., Moutinho, A. F., Mappes, T., Møller, A. P., Mousseau, T. A., & Watts, P. C. (2020). Exposure to environmental radionuclides alters mitochondrial DNA maintenance in a wild rodent. Evolutionary Ecology, 34(2), 163-174. https://doi.org/10.1007/s10682-019-10028-x
Published inEvolutionary Ecology
© The Author(s) 2020
Mitochondria are sensitive to oxidative stress, including that derived from ionizing radiation. To quantify the effects of exposure to environmental radionuclides on mitochondrial DNA (mtDNA) dynamics in wildlife, bank voles (Myodes glareolus) were collected from the chernobyl exclusion zone (CEZ), where animals are exposed to elevated levels of radionuclides, and from uncontaminated areas within the CEZ and elsewhere in Ukraine. Brains of bank voles from outside the CEZ were characterized by low mtDNA copy number and low mtDNA damage; by contrast, bank voles within the CEZ had high mtDNA copy number and high mtDNA damage, consistent with putative damaging effects of elevated radiation and a compensatory response to maintain sufficient functioning mitochondria. In animals outside the CEZ, the expression levels of PGC-1α gene and mtDNA copy number were positively correlated as expected from this gene’s prominent role in mitochondrial biogenesis; this PGC-1α-mtDNA copy number association is absent in samples from the CEZ. Our data imply that exposure to radionuclides is associated with altered mitochondrial dynamics, evident in level of mtDNA and mtDNA damage and the level of activity in mitochondrial synthesis. ...
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Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF
Additional information about fundingOpen access funding provided by University of Oulu including Oulu University Hospital. We acknowledge Gennadi Milinevsky, Igor Chizhevsky, Andrii Simon, Serhii Kirieiev, Anatoly Nosovsky and Maksym Ivanenko for logistic support and help in organizing fieldwork in Ukraine. PCW and TM were funded by Academy of Finland (Project Numbers 287153 and 268670). TAM and APM were supported by awards from the Samuel Freeman Charitable Trust and the American Council of Learned Societies. ...
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Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides Jernfors, Toni; Danforth, John; Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Fajkus, Jiří; Dvořáčková, Martina; Mappes, Tapio; Watts, Phillip C. (John Wiley & Sons, 2021)Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from ...
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