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dc.contributor.authorAlmeida, Gabriel M. F.
dc.contributor.authorLaanto, Elina
dc.contributor.authorAshrafi, Roghaleh
dc.contributor.authorSundberg, Lotta-Riina
dc.date.accessioned2019-11-20T12:11:42Z
dc.date.available2019-11-20T12:11:42Z
dc.date.issued2019
dc.identifier.citationAlmeida, G. M. F., Laanto, E., Ashrafi, R., & Sundberg, L.-R. (2019). Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria. <i>mBio</i>, <i>10</i>(6), Article e01984-19. <a href="https://doi.org/10.1128/mBio.01984-19" target="_blank">https://doi.org/10.1128/mBio.01984-19</a>
dc.identifier.otherCONVID_33588192
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/66452
dc.description.abstractMetazoans were proposed to host bacteriophages on their mucosal surfaces in a symbiotic relationship, where phages provide an external immunity against bacterial infections and the metazoans provide phages a medium for interacting with bacteria. However, scarce empirical evidence and model systems have left the phage-mucus interaction poorly understood. Here, we show that phages bind both to porcine mucus and to rainbow trout (Oncorhynchus mykiss) primary mucus, persist up to 7 days in the mucosa, and provide protection against Flavobacterium columnare. Also, exposure to mucus changes the bacterial phenotype by increasing bacterial virulence and susceptibility to phage infections. This trade-off in bacterial virulence reveals ecological benefit of maintaining phages in the metazoan mucosal surfaces. Tests using other phage-bacterium pairs suggest that phage binding to mucus may be widespread in the biosphere, indicating its importance for disease, ecology, and evolution. This phenomenon may have significant potential to be exploited in preventive phage therapy.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofseriesmBio
dc.rightsCC BY 4.0
dc.subject.otherbacterial virulence
dc.subject.otherbacteriophage therapy
dc.subject.otherbacteriophages
dc.subject.otherhostpathogen interactions
dc.subject.othermucosal pathogens
dc.titleBacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201911204954
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2161-2129
dc.relation.numberinseries6
dc.relation.volume10
dc.type.versionpublishedVersion
dc.rights.copyright© 2019 Almeida et al.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber314939
dc.subject.ysofagiterapia
dc.subject.ysobakteriofagit
dc.subject.ysobakteerit
dc.subject.ysovirulenssi
dc.subject.ysolimakalvot
dc.subject.ysokalataudit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p29496
jyx.subject.urihttp://www.yso.fi/onto/yso/p25303
jyx.subject.urihttp://www.yso.fi/onto/yso/p1749
jyx.subject.urihttp://www.yso.fi/onto/yso/p28481
jyx.subject.urihttp://www.yso.fi/onto/yso/p9294
jyx.subject.urihttp://www.yso.fi/onto/yso/p46
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1128/mBio.01984-19
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThis work was supported by Academy of Finland grants 314939 (L.-R.S.) and 321985 (E.L.) and the Jane and Aatos Erkko Foundation. This work resulted from the BONUS FLAVOPHAGE project supported by BONUS (Art 185), funded jointly by the EU and the Academy of Finland.
dc.type.okmA1


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