Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria
Almeida, Gabriel M. F.; Laanto, Elina; Ashrafi, Roghaleh; Sundberg, Lotta-Riina (2019). Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria. mBio, 10 (6), e01984-19. DOI: 10.1128/mBio.01984-19
© 2019 Almeida et al.
Metazoans were proposed to host bacteriophages on their mucosal surfaces in a symbiotic relationship, where phages provide an external immunity against bacterial infections and the metazoans provide phages a medium for interacting with bacteria. However, scarce empirical evidence and model systems have left the phage-mucus interaction poorly understood. Here, we show that phages bind both to porcine mucus and to rainbow trout (Oncorhynchus mykiss) primary mucus, persist up to 7 days in the mucosa, and provide protection against Flavobacterium columnare. Also, exposure to mucus changes the bacterial phenotype by increasing bacterial virulence and susceptibility to phage infections. This trade-off in bacterial virulence reveals ecological benefit of maintaining phages in the metazoan mucosal surfaces. Tests using other phage-bacterium pairs suggest that phage binding to mucus may be widespread in the biosphere, indicating its importance for disease, ecology, and evolution. This phenomenon may have significant potential to be exploited in preventive phage therapy. ...
PublisherAmerican Society for Microbiology
Publication in research information system
MetadataShow full item record
Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF
Additional information about fundingThis work was supported by Academy of Finland grants 314939 (L.-R.S.) and 321985 (E.L.) and the Jane and Aatos Erkko Foundation. This work resulted from the BONUS FLAVOPHAGE project supported by BONUS (Art 185), funded jointly by the EU and the Academy of Finland.
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Laanto, Elina (University of Jyväskylä, 2014)
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