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dc.contributor.authorvan Bijnen, Sam
dc.contributor.authorKärkkäinen, Salme
dc.contributor.authorHelenius, Päivi
dc.contributor.authorParviainen, Tiina
dc.date.accessioned2019-07-03T05:01:54Z
dc.date.available2019-07-03T05:01:54Z
dc.date.issued2019
dc.identifier.citationvan Bijnen, S., Kärkkäinen, S., Helenius, P., & Parviainen, T. (2019). Left hemisphere enhancement of auditory activation in language impaired children. <i>Scientific Reports</i>, <i>9</i>, Article 9087. <a href="https://doi.org/10.1038/s41598-019-45597-y" target="_blank">https://doi.org/10.1038/s41598-019-45597-y</a>
dc.identifier.otherCONVID_31253207
dc.identifier.otherTUTKAID_81820
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/64970
dc.description.abstractSpecific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.othersensory processing
dc.subject.otherspecific language impartment
dc.subject.otherauditory response
dc.titleLeft hemisphere enhancement of auditory activation in language impaired children
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201907023545
dc.contributor.laitosMatematiikan ja tilastotieteen laitosfi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Mathematics and Statisticsen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineTilastotiedefi
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineStatisticsen
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-07-02T12:15:16Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors, 2019.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber641652
dc.relation.grantnumber641652
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/641652/EU//ChildBrain
dc.subject.ysoneurofysiologia
dc.subject.ysokielellinen erityisvaikeus
dc.subject.ysokuulo
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p2316
jyx.subject.urihttp://www.yso.fi/onto/yso/p12073
jyx.subject.urihttp://www.yso.fi/onto/yso/p1937
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-019-45597-y
dc.relation.funderEuroopan komissiofi
dc.relation.funderEuropean Commissionen
jyx.fundingprogramMSCA Marie Skłodowska-Curie Actions, H2020fi
jyx.fundingprogramMSCA Marie Skłodowska-Curie Actions, H2020en


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