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dc.contributor.authorvan Bijnen, Sam
dc.contributor.authorKärkkäinen, Salme
dc.contributor.authorHelenius, Päivi
dc.contributor.authorParviainen, Tiina
dc.date.accessioned2019-07-03T05:01:54Z
dc.date.available2019-07-03T05:01:54Z
dc.date.issued2019
dc.identifier.citationvan Bijnen, S., Kärkkäinen, S., Helenius, P., & Parviainen, T. (2019). Left hemisphere enhancement of auditory activation in language impaired children. <i>Scientific Reports</i>, <i>9</i>, Article 9087. <a href="https://doi.org/10.1038/s41598-019-45597-y" target="_blank">https://doi.org/10.1038/s41598-019-45597-y</a>
dc.identifier.otherCONVID_31253207
dc.identifier.otherTUTKAID_81820
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/64970
dc.description.abstractSpecific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.othersensory processing
dc.subject.otherspecific language impartment
dc.subject.otherauditory response
dc.titleLeft hemisphere enhancement of auditory activation in language impaired children
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201907023545
dc.contributor.laitosMatematiikan ja tilastotieteen laitosfi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Mathematics and Statisticsen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineTilastotiedefi
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineStatisticsen
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-07-02T12:15:16Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors, 2019.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber641652
dc.relation.grantnumber641652
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/641652/EU//ChildBrain
dc.subject.ysoneurofysiologia
dc.subject.ysokehityksellinen kielihäiriö
dc.subject.ysokuulo
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p2316
jyx.subject.urihttp://www.yso.fi/onto/yso/p12073
jyx.subject.urihttp://www.yso.fi/onto/yso/p1937
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-019-45597-y
dc.relation.funderEuroopan komissiofi
dc.relation.funderEuropean Commissionen
jyx.fundingprogramMSCA Marie Skłodowska-Curie Actions, H2020fi
jyx.fundingprogramMSCA Marie Skłodowska-Curie Actions, H2020en
dc.type.okmA1


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