Left hemisphere enhancement of auditory activation in language impaired children
van Bijnen, S., Kärkkäinen, S., Helenius, P., & Parviainen, T. (2019). Left hemisphere enhancement of auditory activation in language impaired children. Scientific Reports, 9, Article 9087. https://doi.org/10.1038/s41598-019-45597-y
Published inScientific Reports
DisciplineTilastotiedePsykologiaMonitieteinen aivotutkimuskeskusStatisticsPsychologyCentre for Interdisciplinary Brain Research
© The Authors, 2019.
Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development. ...
PublisherNature Publishing Group
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Related funder(s)European Commission
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