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dc.contributor.authorHaapanen, Markus J.
dc.contributor.authorPerälä, Mia-Maria
dc.contributor.authorSalonen, Minna K.
dc.contributor.authorGuzzardi, Maria A.
dc.contributor.authorIozzo, Patricia
dc.contributor.authorKajantie, Eero
dc.contributor.authorRantanen, Taina
dc.contributor.authorSimonen, Mika
dc.contributor.authorPohjolainen, Pertti
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorvon Bonsdorff, Mikaela
dc.date.accessioned2018-08-10T04:42:56Z
dc.date.available2018-08-10T04:42:56Z
dc.date.issued2018fi
dc.identifier.citationHaapanen, M. J., Perälä, M.-M., Salonen, M. K., Guzzardi, M. A., Iozzo, P., Kajantie, E., . . . von Bonsdorff, M. (2018). Telomere Length and Frailty : The Helsinki Birth Cohort Study. <em>Journal of the American Medical Directors Association</em>, 19 (8), 658-662. <a href="https://doi.org/10.1016/j.jamda.2018.05.011">doi:10.1016/j.jamda.2018.05.011</a>fi
dc.identifier.otherTUTKAID_78130
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59181
dc.description.abstractObjectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in telomere length and frailty exist. Design: Longitudinal cohort study. Setting and participants: A subpopulation of the Helsinki Birth Cohort Study consisting of 1078 older adults aged 67 to 79 years born in Helsinki, Finland, between 1934 and 1944. Measures: Relative leukocyte telomere length (LTL) was measured using quantitative real-time polymerase chain reaction at the average ages of 61 and 71 years, and at the latter the participants were assessed for frailty according to Fried criteria. Results: The mean SD relative LTLs were 1.40 0.29 (average age 61 years) and 0.86 0.30 (average age 71 years) for the cohort. A trend of shorter mean relative LTL across frailty groups was observed at 61 years (P ¼ .016) and at 71 years (P ¼ .057). Relative LTL at age 61 years was significantly associated with frailty: per 1-unit increase in relative LTL, the corresponding relative risk ratio (RRR) of frailty was 0.28 (95% confidence interval [CI] 0.08e0.97), adjusting for several confounders. Also, LTL at age 71 years was associated with frailty (RRR 0.18, 95% CI 0.04e0.81) after adjustment for sex, age, and adult socioeconomic status, but further adjustment attenuated the association. No associations between telomere shortening and frailty were observed during the 10-year follow-up. Conclusions: Shorter relative LTL was associated with frailty in cross-sectional and longitudinal analyses, but telomere shortening was not, suggesting that short LTL may be a biomarker of frailty.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.ispartofseriesJournal of the American Medical Directors Association
dc.rightsCC BY-NC-ND
dc.subject.othertelomeeritfi
dc.subject.othervanheneminenfi
dc.subject.otherhauraus-raihnausoireyhtymäfi
dc.subject.othermarkkeritfi
dc.subject.otherbiomarkerfi
dc.subject.otherfrailtyfi
dc.subject.othertelomerefi
dc.titleTelomere Length and Frailty : The Helsinki Birth Cohort Studyfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201807263639
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-07-26T09:15:10Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange658-662
dc.relation.issn1538-9375
dc.relation.numberinseries8
dc.relation.volume19
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.jamda.2018.05.011


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