Telomere length and physical performance among older people : the Helsinki Birth Cohort Study
Åström, M. J., von Bonsdorff, M. B., Perälä, M.-M., Salonen, M. K., Rantanen, T., Kajantie, E., Simonen, M., Pohjolainen, P., Haapanen, M. J., Guzzardi, M. A., Iozzo, P., Kautiainen, H., & Eriksson, J. G. (2019). Telomere length and physical performance among older people : the Helsinki Birth Cohort Study. Mechanisms of Ageing and Development, 183, Article 111145. https://doi.org/10.1016/j.mad.2019.111145
Published inMechanisms of Ageing and Development
© 2019 Published by Elsevier B.V.
Telomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the Helsinki Birth Cohort Study at two time-points; a baseline examination in 2001-2004 at a mean age of 61 years and a follow-up examination approximately 10 years later in 2011-2013. Telomere length was measured both at baseline and at follow-up using real-time quantitative polymerase chain reaction. Physical performance was evaluated only at follow-up using the Senior Fitness Test (SFT), which assesses strength, flexibility and endurance. In women, shorter telomere length at follow-up (p = 0.044) and greater telomere attrition during follow-up time (p = 0.022) were associated with poorer physical performance after adjusting for covariates (age at baseline, smoking status, body mass index at baseline, follow-up time and educational attainment). No similar associations were found for men. This indicates that, at least in women, telomere length could potentially be used as a biomarker for physical performance, however, more longitudinal studies are needed to confirm this association. ...
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Additional information about fundingThis work was supported by Emil Aaltonen Foundation; Finnish Foundation for Cardiovascular Research; Finnish Foundation for Diabetes Research; Finnish Foundation for Pediatric Research; Juho Vainio Foundation; Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Samfundet Folkhälsan; Finska Läkaresällskapet; Liv och Hälsa; European Commission FP7 DORIAN [grant number 278603]; EU H2020-PHC-2014-DynaHealth [grant number 633595]; and Academy of Finland [grant numbers 257239 to MBvB, 127437 to EK, 129306 to EK, 130326 to EK, 134791 to EK, 263924 to EK, 274794 to EK, 129369 to JGE, 129907 to JGE, 135072 to JGE, 129255 to JGE, 126775 to JGE]. ...
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Haapanen, Markus J.; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria A.; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; von Bonsdorff, Mikaela (Elsevier Inc., 2018)Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in ...
Åström, Max J.; von Bonsdorff, Mikaela B.; Salonen, Minna K.; Kajantie, Eero; Osmond, Clive; Eriksson, Johan G. (Elsevier, 2021)Aim : This study aimed to assess the association between grip strength and glucose regulation in a cross-sectional setting. Methods : Using data from the Helsinki Birth Cohort Study, 924 men and 953 women were studied ...
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