Näytä suppeat kuvailutiedot

dc.contributor.authorRonkainen, Paula
dc.contributor.authorKovanen, Vuokko
dc.contributor.authorAlén, Markku
dc.contributor.authorLaakkonen, Eija
dc.contributor.authorPalonen, Eeva-Maija
dc.contributor.authorAnkarberg-Lindgren, Carina
dc.contributor.authorHämäläinen, Esa
dc.contributor.authorTurpeinen, Ursula
dc.contributor.authorKujala, Urho
dc.contributor.authorPuolakka, Jukka
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorSipilä, Sarianna
dc.date.accessioned2017-05-18T06:43:24Z
dc.date.available2017-05-18T06:43:24Z
dc.date.issued2009
dc.identifier.citationRonkainen, P., Kovanen, V., Alén, M., Laakkonen, E., Palonen, E.-M., Ankarberg-Lindgren, C., Hämäläinen, E., Turpeinen, U., Kujala, U., Puolakka, J., Kaprio, J., & Sipilä, S. (2009). Postmenopausal Hormone Replacement Therapy Modifies Skeletal Muscle Composition and Function: A Study with Monozygotic Twin Pairs. <i>The Journal of Applied Physiology</i>, <i>107</i>(1), 25-33. <a href="https://doi.org/10.1152/japplphysiol.91518.2008" target="_blank">https://doi.org/10.1152/japplphysiol.91518.2008</a>
dc.identifier.otherCONVID_18632726
dc.identifier.otherTUTKAID_34880
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/54013
dc.description.abstractWe investigated whether long-term hormone replacement therapy (HRT) is associated with mobility and lower limb muscle performance and composition in postmenopausal women. Fifteen 54- to 62-yr-old monozygotic female twin pairs discordant for HRT were recruited from the Finnish Twin Cohort. Habitual (HWS) and maximal (MWS) walking speeds over 10 m, thigh muscle composition, lower body muscle power assessed as vertical jumping height, and maximal isometric hand grip and knee extension strengths were measured. Intrapair differences (IPD%) with 95% confidence intervals (CI) were calculated. The mean duration of HRT use was 6.9 ± 4.1 yr. MWS was on average 7% (0.9 to 13.1%, P = 0.019) and muscle power 16% (−0.8 to 32.8%, P = 0.023) greater in HRT users than in their cotwins. Thigh muscle cross-sectional area tended to be larger (IPD% = 6%, 95% CI: −0.07 to 12.1%, P = 0.065), relative muscle area greater (IPD% = 8%, CI: 0.8 to 15.0%, P = 0.047), and relative fat area smaller (IPD% = −5%, CI: −11.3 to 1.2%, P = 0.047) in HRT users than in their sisters. There were no significant differences in maximal isometric strengths or HWS between users and nonusers. Subgroup analyses revealed that estrogen-containing therapies (11 pairs) significantly decreased total body and thigh fat content, whereas tibolone (4 pairs) tended to increase muscle cross-sectional area. This study showed that long-term HRT was associated with better mobility, greater muscle power, and favorable body and muscle composition among 54- to 62-yr-old women. The results indicate that HRT is a potential agent in preventing muscle weakness and mobility limitation in older women.
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesThe Journal of Applied Physiology
dc.subject.otherIkääntymien
dc.subject.otherlihaksen voimantuottoteho
dc.subject.otherAging
dc.subject.othermuscle power
dc.titlePostmenopausal Hormone Replacement Therapy Modifies Skeletal Muscle Composition and Function: A Study with Monozygotic Twin Pairs
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201705082236
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-05-08T12:15:36Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange25-33
dc.relation.issn0522-1601
dc.relation.numberinseries1
dc.relation.volume107
dc.type.versionacceptedVersion
dc.rights.copyright© 2009 the American Physiological Society. This is a final draft version of an article whose final and definitive form has been published by APS. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysovaihdevuodet
dc.subject.ysosukupuolihormonit
dc.subject.ysolihasvoima
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
jyx.subject.urihttp://www.yso.fi/onto/yso/p10984
jyx.subject.urihttp://www.yso.fi/onto/yso/p23362
dc.relation.doi10.1152/japplphysiol.91518.2008
dc.type.okmA1


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot