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dc.contributor.authorVoutilainen, Liina
dc.contributor.authorKallio, Eva
dc.contributor.authorNiemimaa, Jukka
dc.contributor.authorVapalahti, Olli
dc.contributor.authorHenttonen, Heikki
dc.date.accessioned2016-03-16T09:48:30Z
dc.date.available2016-03-16T09:48:30Z
dc.date.issued2016
dc.identifier.citationVoutilainen, L., Kallio, E., Niemimaa, J., Vapalahti, O., & Henttonen, H. (2016). Temporal dynamics of Puumala hantavirus infection in cyclic populations of bank voles. <em>Scientific Reports</em>, 6, 21323. <a href="http://dx.doi.org/10.1038/srep21323">doi:10.1038/srep21323</a>
dc.identifier.otherTUTKAID_69401
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49077
dc.description.abstractUnderstanding the dynamics of zoonotic pathogens in their reservoir host populations is a prerequisite for predicting and preventing human disease epidemics. The human infection risk of Puumala hantavirus (PUUV) is highest in northern Europe, where populations of the rodent host (bank vole, Myodes glareolus) undergo cyclic fluctuations. We conducted a 7-year capture-mark-recapture study to monitor seasonal and multiannual patterns of the PUUV infection rate in bank vole populations exhibiting a 3-year density cycle. Infected bank voles were most abundant in mid-winter months during years of increasing or peak host density. Prevalence of PUUV infection in bank voles exhibited a regular, seasonal pattern reflecting the annual population turnover and accumulation of infections within each year cohort. In autumn, the PUUV transmission rate tracked increasing host abundance, suggesting a density-dependent transmission. However, prevalence of PUUV infection was similar during the increase and peak years of the density cycle despite a twofold difference in host density. This may result from the high proportion of individuals carrying maternal antibodies constraining transmission during the cycle peak years. Our exceptionally intensive and long-term dataset provides a solid basis on which to develop models to predict the dynamic public health threat posed by PUUV in northern Europe.
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.subject.otherzoonotic pathogens
dc.subject.otherPuumala hantavirus
dc.subject.otherbank vole
dc.subject.otherMyodes glareolus
dc.subject.otherinfection rate
dc.subject.othercyclic fluctuations
dc.titleTemporal dynamics of Puumala hantavirus infection in cyclic populations of bank voles
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201603091798
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosThe Department of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doi10.1038/srep21323
dc.date.updated2016-03-09T10:15:02Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.volume6
dc.type.versionpublishedVersion
dc.rights.copyright© 2016 the Authors. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0/


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© 2016 the Authors. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as © 2016 the Authors. This is an open access article licensed under a Creative Commons Attribution 4.0 International License.