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Eco-epidemiology of tick- and rodent-borne pathogens in boreal forests
DisciplineEkologia ja evoluutiobiologia
Infectious diseases are amongst the ten major causes of human mortality worldwide, 60% of them being animal-borne. Variations of abiotic and biotic conditions are likely to modify the transmission of parasites and pathogens within reservoir species, and, as a consequence, alter the zoonotic risk for human. My thesis aims at elucidating the dynamics and mechanisms of the maintenance of ticks, tick-borne pathogens (TBPs) and the Puumala hantavirus (PUUV) in the reservoir host, the bank vole (Myodes glareolus, BV). In Northern Europe, tick-borne diseases are growing in importance to human because of the latitudinal expansion of the tick Ixodes ricinus. Field monitoring revealed that I. ricinus was the only species found in the vegetation in Central Finland. The abundance of immature I. ricinus in nature was positively associated with the BV abundance. The highest risk periods for tick bites on humans were May– June and September. Ixodes ricinus was positively associated with open water coverage and human density, which might offer suitable moisture conditions and anthropogenic modifications favouring the species. The infection of BV with the zoonotic B. burgdorferi s.l. was associated with the abundance of I. ricinus at the site, indicating that this tick species was required for the transmission and persistence of this pathogen. An experiment revealed, for the first time, that B. afzelii can modify the behaviour and the breeding success of its host, and these effects are both sex- and size-specific and density-dependent. Space-state modelling of longitudinal field data revealed that PUUV infection likelihood was the lowest in BV previously infested with vectors in comparison to Anaplasma phagocytophilum infected BV, or individuals without any previous infections. Altogether, this study shows how seasonality, co-infecting pathogens and host population density influence the risk of tick-borne pathogens and the zoonotic risk in Central Finland. ...
PublisherUniversity of Jyväskylä
ISSN Search the Publication Forum1456-9701
Borrelia burgdorferi s.l Myodes glareolus Puumala hantavirus disease ecology eco-epidemiology reservoir tick-borne pathogens puutiaiset punkit taudinaiheuttajat Borrelia-bakteerit Puumala-virus leviäminen isäntäeläimet myyrät metsämyyrä jyrsijät metsäekosysteemit populaatioekologia boreaalinen vyöhyke ekologia epidemiologia hantavirukset zoonoosit
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Predicting habitat suitability for Ixodes ricinus and Ixodes persulcatus ticks in Finland Uusitalo, Ruut; Siljander, Mika; Lindén, Andreas; Sormunen, Jani J.; Aalto, Juha; Hendrickx, Guy; Kallio, Eva; Vajda, Andrea; Gregow, Hilppa; Henttonen, Heikki; Marsboom, Cedric; Korhonen, Essi M.; Sironen, Tarja; Pellikka, Petri; Vapalahti, Olli (Biomed Central, 2022)Background Ticks are responsible for transmitting several notable pathogens worldwide. Finland lies in a zone where two human-biting tick species co-occur: Ixodes ricinus and Ixodes persulcatus. Tick densities have increased ...
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe Aminikhah, Mahdi; Forsman, Jukka T.; Koskela, Esa; Mappes, Tapio; Sane, Jussi; Ollgren, Jukka; Kivelä, Sami M.; Kallio, Eva R. (Nature Publishing Group, 2021)Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population ...
Monitoring of ticks and tick-borne pathogens through a nationwide research station network in Finland Sormunen, Jani J.; Andersson, Tommi; Aspi, Jouni; Bäck, Jaana; Cederberg, Tony; Haavisto, Noora; Halonen, Hanna; Hänninen, Jari; Inkinen, Jasmin; Kulha, Niko; Laaksonen, Maija; Loehr, John; Mäkelä, Satu; Mäkinen, Katja; Norkko, Joanna; Paavola, Riku; Pajala, Pauliina; Petäjä, Tuukka; Puisto, Anna; Sippola, Ella; Snickars, Martin; Sundell, Janne; Tanski, Niko; Uotila, Antti; Vesilahti, Ella-Maria; Vesterinen, Eero J.; Vuorenmaa, Silja; Ylönen, Hannu; Ylönen, Jari; Klemola, Tero (Elsevier, 2020)In 2015 a long-term, nationwide tick and tick-borne pathogen (TBP) monitoring project was started by the Finnish Tick Project and the Finnish Research Station network (RESTAT), with the goal of producing temporally and ...
Sympatric Ixodes-tick species : pattern of distribution and pathogen transmission within wild rodent populations Cayol, Claire; Jääskeläinen, Anu; Koskela, Esa; Kyröläinen, Sami; Mappes, Tapio; Siukkola, Anja; Kallio, Eva (Nature Publishing Group, 2018)The generalist tick Ixodes ricinus is the most important vector for tick-borne pathogens (TBP), including Borrelia burgdorferi sensu lato, in Europe. However, the involvement of other sympatric Ixodes ticks, such as the ...
Borrelia afzelii alters reproductive success in a rodent host Cayol, Claire; Giermek, Anna; Gomez-Chamorro, Andrea; Hytönen, Jukka; Kallio, Eva; Mappes, Tapio; Salo, Jemiina; Voordouw, Maarten Jeroen; Koskela, Esa (The Royal Society Publishing, 2018)The impact of a pathogen on the fitness and behaviour of its natural host depends upon the host–parasite relationship in a given set of environmental conditions. Here, we experimentally investigated the effects of Borrelia ...