The impact of wildlife and environmental factors on hantavirus infection in the host and its translation into human risk
Wang, Y. X. G., Voutilainen, L., Aminikhah, M., Helle, H., Huitu, O., Laakkonen, J., Lindén, A., Niemimaa, J., Sane, J., Sironen, T., Vapalahti, O., Henttonen, H., & Kallio, E. R. (2023). The impact of wildlife and environmental factors on hantavirus infection in the host and its translation into human risk. Proceedings of the Royal Society B : Biological Sciences, 290(1996), Article 20222470. https://doi.org/10.1098/rspb.2022.2470
DisciplineResurssiviisausyhteisöEvoluutiotutkimus (huippuyksikkö)Ekologia ja evoluutiobiologiaSchool of Resource WisdomCentre of Excellence in Evolutionary ResearchEcology and Evolutionary Biology
© 2023 the Authors
Identifying factors that drive infection dynamics in reservoir host populations is essential in understanding human risk from wildlife-originated zoonoses. We studied zoonotic Puumala orthohantavirus (PUUV) in the host, the bank vole (Myodes glareolus), populations in relation to the host population, rodent and predator community and environment-related factors and whether these processes are translated into human infection incidence. We used 5-year rodent trapping and bank vole PUUV serology data collected from 30 sites located in 24 municipalities in Finland. We found that PUUV seroprevalence in the host was negatively associated with the abundance of red foxes, but this process did not translate into human disease incidence, which showed no association with PUUV seroprevalence. The abundance of weasels, the proportion of juvenile bank voles in the host populations and rodent species diversity were negatively associated with the abundance index of PUUV positive bank voles, which, in turn, showed a positive association with human disease incidence. Our results suggest certain predators, a high proportion of young bank vole individuals, and a diverse rodent community, may reduce PUUV risk for humans through their negative impacts on the abundance of infected bank voles. ...
PublisherThe Royal Society Publishing
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Related funder(s)Academy of Finland
Funding program(s)Academy Research Fellow, AoF; Research costs of Academy Research Fellow, AoF; Academy Programme, AoF
Additional information about fundingThis research was funded by EU FP5 project QLRT–2001–01358 and European Commission Project GOCE–CT–2003–010284 EDEN to H.H. and Academy of Finland (grant nos. 329332, 329308 and 335651 to E.R.K.).
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