Physical activity in adulthood : genes and mortality
Karvinen, S., Waller, K., Silvennoinen, M., Koch, L. G., Britton, S. L., Kaprio, J., Kainulainen, H., & Kujala, U. (2015). Physical activity in adulthood : genes and mortality. Scientific Reports, 5, Article 18259. https://doi.org/10.1038/srep18259
Julkaistu sarjassa
Scientific ReportsTekijät
Päivämäärä
2015Tekijänoikeudet
© the Authors 2015. Published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License.
2016:47 | 2017:144 | 2018:198 | 2019:86 | 2020:89 | 2021:65 | 2022:52 | 2023:56 | 2024:45 | 2025:2
Observational studies report a strong inverse relationship between leisure-time physical activity and allcause
mortality. Despite suggestive evidence from population-based associations, scientists have not
been able to show a beneficial effect of physical activity on the risk of death in controlled intervention
studies among individuals who have been healthy at baseline. On the other hand, high cardiorespiratory
fitness is known to be a strong predictor of reduced mortality, even more robust than physical activity
level itself. Here, in both animals and/or human twins, we show that the same genetic factors influence
physical activity levels, cardiorespiratory fitness, and risk of death. Previous observational follow-up
studies in humans suggest that increasing fitness through physical activity levels could prolong life;
however, our controlled interventional study with laboratory rats bred for low and high intrinsic fitness
contrast with these findings. Also, we find no evidence for the suggested association using pairwise
analysis among monozygotic twin pairs who are discordant in their physical activity levels. Based on
both our animal and human findings, we propose that genetic pleiotropy might partly explain the
frequently observed associations between high baseline physical activity and later reduced mortality in
humans.
...
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Nature Publishing GroupISSN Hae Julkaisufoorumista
2045-2322Asiasanat
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