Näytä suppeat kuvailutiedot

dc.contributor.authorKarvinen, Sira
dc.contributor.authorWaller, Katja
dc.contributor.authorSilvennoinen, Mika
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKainulainen, Heikki
dc.contributor.authorKujala, Urho
dc.date.accessioned2016-01-05T05:47:57Z
dc.date.available2016-01-05T05:47:57Z
dc.date.issued2015
dc.identifier.citationKarvinen, S., Waller, K., Silvennoinen, M., Koch, L. G., Britton, S. L., Kaprio, J., Kainulainen, H., & Kujala, U. (2015). Physical activity in adulthood : genes and mortality. <i>Scientific Reports</i>, <i>5</i>, Article 18259. <a href="https://doi.org/10.1038/srep18259" target="_blank">https://doi.org/10.1038/srep18259</a>
dc.identifier.otherCONVID_25406975
dc.identifier.otherTUTKAID_68401
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/48243
dc.description.abstractObservational studies report a strong inverse relationship between leisure-time physical activity and allcause mortality. Despite suggestive evidence from population-based associations, scientists have not been able to show a beneficial effect of physical activity on the risk of death in controlled intervention studies among individuals who have been healthy at baseline. On the other hand, high cardiorespiratory fitness is known to be a strong predictor of reduced mortality, even more robust than physical activity level itself. Here, in both animals and/or human twins, we show that the same genetic factors influence physical activity levels, cardiorespiratory fitness, and risk of death. Previous observational follow-up studies in humans suggest that increasing fitness through physical activity levels could prolong life; however, our controlled interventional study with laboratory rats bred for low and high intrinsic fitness contrast with these findings. Also, we find no evidence for the suggested association using pairwise analysis among monozygotic twin pairs who are discordant in their physical activity levels. Based on both our animal and human findings, we propose that genetic pleiotropy might partly explain the frequently observed associations between high baseline physical activity and later reduced mortality in humans.
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.subject.otherphysical activity
dc.subject.othermortality
dc.titlePhysical activity in adulthood : genes and mortality
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201601041004
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-01-04T10:15:06Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume5
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors 2015. Published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysogeenit
dc.subject.ysoaikuiset
jyx.subject.urihttp://www.yso.fi/onto/yso/p147
jyx.subject.urihttp://www.yso.fi/onto/yso/p5590
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/srep18259
dc.type.okmA1


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Näytä suppeat kuvailutiedot

© the Authors 2015. Published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License.
Ellei muuten mainita, aineiston lisenssi on © the Authors 2015. Published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License.