Association between low-frequency ultrasound and hip fractures - comparison with DXA-based BMD
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Määttä, M., Moilanen, P., Timonen, J., Pulkkinen, P., Korpelainen, R., & Jämsä, T. (2014). Association between low-frequency ultrasound and hip fractures - comparison with DXA-based BMD. BMC Musculoskeletal Disorders, 15(208). https://doi.org/10.1186/1471-2474-15-208
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BMC Musculoskeletal DisordersAuthors
Date
2014Copyright
© 2014 Määttä et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited
Background:
New methods for diagnosing osteoporosis and evaluating fracture risk are being developed. We aim
to study the association between low-frequency (LF) axial transmission ultrasound and hip fracture risk in a
population-based sample of older women.
Methods:
The study population consisted of 490 community-dwelling women (78
–
82 years). Ultrasound velocity
(V
LF
) at mid-tibia was measured in 2006 using a low-frequency scanning axial transmission device. Bone mineral
density (BMD) at proximal femur measured using dual-energy x-ray absorptiometry (DXA) was used as the reference
method. The fracture history of the participants was collected from December 1997 until the end of 2010.
Lifestyle-related risk factors and mobility were assessed at 1997.
Results:
During the total follow-up period (1997
–
2010), 130 women had one or more fractures, and 20 of them
had a hip fracture. Low V
LF
(the lowest quartile) was associated with increased hip fracture risk when compared
with V
LF
in the normal range (Odds ratio, OR = 3.3, 95% confidence interval (CI) 1.3-8.4). However, V
LF
was not
related to fracture risk when all bone sites were considered. Osteoporotic femoral neck BMD was associated with
higher risk of a hip fracture (OR = 4.1, 95% CI 1.6-10.5) and higher risk of any fracture (OR = 2.4, 95% CI 1.6-3.8)
compared to the non-osteoporotic femoral neck BMD. Decreased V
LF
remained a significant risk factor for hip
fracture when combined with lifestyle-related risk factors (OR = 3.3, 95% CI 1.2-9.0).
Conclusion:
Low V
LF
was associated with hip fracture risk in older women even when combined with
lifestyle-related risk factors. Further development of the method is needed to improve the measurement precision
and to confirm the results.
...
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BioMed Central Ltd.ISSN Search the Publication Forum
1471-2474
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http://www.biomedcentral.com/1471-2474/15/208Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/23676293
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Except where otherwise noted, this item's license is described as © 2014 Määttä et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited
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