Longitudinal associations of high‐volume and vigorous‐intensity exercise with hip fracture risk in men
Korhonen, M. T., Kujala, U. M., Kettunen, J., Korhonen, O. V., Kaprio, J., Sarna, S., & Törmäkangas, T. (2022). Longitudinal associations of high‐volume and vigorous‐intensity exercise with hip fracture risk in men. Journal of Bone and Mineral Research, 37(8), 1562-1570. https://doi.org/10.1002/jbmr.4624
Published inJournal of Bone and Mineral Research
DisciplineGerontologia ja kansanterveysLiikuntalääketiedeGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthSports and Exercise MedicineGerontology Research CenterSchool of Wellbeing
© 2022 the Authors
Maintenance of vigorous exercise habits from young to old age is considered protective against hip fractures, but data on fracture risk in lifelong vigorous exercisers are lacking. This longitudinal cohort study examined the hazard of hip fractures in 1844 male former athletes and 1216 population controls and in relation to exercise volume and intensity in later years. Incident hip fractures after age 50 were identified from hospital discharge register from 1972 to 2015. Exercise and covariate information was obtained from questionnaires administered in 1985, 1995, 2001 and 2008. Analyses were conducted using extended proportional hazards regression model for time-dependent exposures and effects. During the mean (SD) follow-up of 21.6 (10.3) years, 62 (3.4%) athletes and 38 (3.1%) controls sustained a hip fracture. Adjusted hazard ratio, HR, indicated no statistically significantly difference between athletes and controls (0.84; 95% CI, 0.55, 1.29). In subgroup analyses, adjusted HRs for athletes with recent high (≥ 15 MET-h/wk) and low (< 15 MET-h/wk) exercise volume were 0.83 (95% CI, 0.46, 1.48) and 1.04 (95% CI, 0.57, 1.87), respectively, compared with controls. The adjusted HR was not statistically significant between athletes with low-intensity exercise (< 6 METs) and controls (1.08; 95% CI, 0.62, 1.85). Athletes engaging in vigorous-intensity exercise (≥ 6 METs at least 75 min/wk) had initially 77% lower hazard rate (adjusted HR, 0.23; 95% CI, 0.06, 0.86) than controls. However, the hazard ratio was time-dependent (adjusted HR, 1.04; 95% CI, 1.01, 1.07); by age 75 years the hazards for the athletes with vigorous-intensity exercise reached the level of the controls, but after 85 years the hazards for these athletes increased approximately 1.3-fold annually relative to the controls. In conclusion, these data suggest that continuation of vigorous-intensity exercise is associated with lower hazard rate of hip fracture up to old age. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Related funder(s)Academy of Finland
Funding program(s)Postdoctoral Researcher, AoF
Additional information about fundingThe study was supported by the Ministry of Education and Culture Finland, Juho Vainio Foundation, Päivikki and Sakari Sohlberg Foundation, Yrjö Jahnsson Foundation, Alfred Kordelin Foundation, and the Academy of Finland (grant no. 336823 to JK and 286536 to TT)
Showing items with similar title or keywords.
Effects of home-based physical exercise on days at home, healthcare utilization and functional independence among patients with hip fractures : a randomized controlled trial Soukkio, Paula K.; Suikkanen, Sara A.; Aartolahti, Eeva M.; Kautiainen, Hannu; Kääriä, Sanna M.; Hupli, Markku T.; Pitkälä, Kaisu H.; Sipilä, Sarianna; Kukkonen-Harjula, Katriina T. (Elsevier, 2021)Objective To evaluate the effects of a physical exercise program on days lived at home, the use and costs of healthcare and social services mortality and functional independence among patients with hip fractures. Des ...
Effects of a 12-month home-based exercise program on functioning after hip fracture : Secondary analyses of an RCT Soukkio, Paula K.; Suikkanen, Sara A.; Kukkonen‐Harjula, Katriina T.; Kautiainen, Hannu; Hupli, Markku T.; Aartolahti, Eeva M.; Kääriä, Sanna M.; Pitkälä, Kaisu H.; Sipilä, Sarianna (Wiley-Blackwell, 2022)Background Long-term functional limitations are common after hip fractures. Exercise may alleviate these negative consequences but there is no consensus on an optimal training program. The objective was to study the effects ...
Greater maintenance of bone mineral content in male than female athletes and in sprinting and jumping than endurance athletes : a longitudinal study of bone strength in elite masters athletes Ireland, Alex; Mittag, Uwe; Degens, Hans; Felsenberg, Dieter; Ferretti, José L.; Heinonen, Ari; Koltai, Erika; Korhonen, Marko T.; McPhee, Jamie S.; Mekjavic, Igor; Piasecki, Jessica; Pisot, Rado; Radak, Zsolt; Simunic, Bostjan; Suominen, Harri; Wilks, Désirée C.; Winwood, Keith; Rittweger, Jörn (Springer, 2020)We investigated longitudinal changes in tibia bone strength in master power (jumping and sprinting) and endurance (distance) athletes of both sexes. Bone mass but not cross-sectional moment of inertia was better maintained ...
Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond : why and how : a position statement from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology Hansen, Dominique; Abreu, Ana; Ambrosetti, Marco; Cornelissen, Veronique; Gevaert, Andreas; Kemps, Hareld; Laukkanen, Jari A; Pedretti, Roberto; Simonenko, Maria; Wilhelm, Matthias; Davos, Constantinos H.; Doehner, Wolfram; Iliou, Marie-Christine; Kränkel, Nicolle; Völler, Heinz; Piepoli, Massimo (Oxford University Press (OUP), 2022)A proper determination of the exercise intensity is important for the rehabilitation of patients with cardiovascular disease (CVD) since it affects the effectiveness and medical safety of exercise training. In 2013, the ...
Mikkola, Tuija (University of Jyväskylä, 2010)