Association of Body Size at Birth and Childhood Growth with Hip Fractures in Older Age : An Exploratory Follow-up of the Helsinki Birth Cohort Study
Mikkola, T., von Bonsdorff, M., Osmond, C., Salonen, M. K., Kajantie, E., & Eriksson, J. G. (2017). Association of Body Size at Birth and Childhood Growth with Hip Fractures in Older Age : An Exploratory Follow-up of the Helsinki Birth Cohort Study. Journal of Bone and Mineral Research, 32(6), 1194-1200. https://doi.org/10.1002/jbmr.3100
Published inJournal of Bone and Mineral Research
© 2017 American Society for Bone and Mineral Research. This is a final draft version of an article whose final and definitive form has been published by Wiley. Published in this repository with the kind permission of the publisher.
Childhood growth has been linked with bone properties in adulthood, whereas less is known about the contribution of early growth to bone fracture risk. We investigated the association of body size at birth and childhood growth with hip fractures and pharmacotherapy for osteoporosis in older age. Men and women, born full term, from the Helsinki Birth Cohort Study (n = 8345) were followed until the age of 68 to 80 years. Height and weight from birth to 11 years were obtained from health care records and diagnoses of hip fractures and osteoporosis drug purchases from national registers. Independent associations of each age period were analyzed using Cox models adjusted for age, childhood and adulthood socioeconomic status, and drugs affecting bone metabolism. In men, the risk of hip fractures was nonlinearly associated with childhood growth. Compared to intermediate increase, low and high increase in height between 2 and 7 years (p < 0.001) were associated with all hip fractures and hip fractures sustained after the age of 50 years. Further, compared to intermediate gain, low and high gain in BMI between 7 and 11 years (p = 0.001) were associated with greater risk of hip fractures in men. In women, growth was not associated with the risk of hip fractures but greater weight (hazard ratio [HR] = 0.85; 95% CI, 0.77 to 0.94; p = 0.001) and BMI (HR 0.86; 95% CI, 0.78 to 0.95; p = 0.003) gain between ages 2 and 7 years were associated with a decreased risk of pharmacotherapy for osteoporosis. In men, growth was not associated with the risk of pharmacotherapy for osteoporosis. In conclusion, growth during childhood may contribute to the risk of hip fractures in later life among men. ...
PublisherAmerican Society for Bone and Mineral Research; Wiley
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Childhood growth predicts higher bone mass and greater bone area in early old age : findings among a subgroup of women from the Helsinki Birth Cohort Study Mikkola, Tuija; von Bonsdorff, Mikaela; Osmond, C.; Salonen, M. K.; Kajantie, E.; Cooper, C.; Välimäki, M. J.; Eriksson, J. G. (Springer UK, European Foundation for Osteoporosis, 2017)Summary We examined the associations between childhood growth and bone properties among women at early old age. Early growth in height predicted greater bone area and higher bone mineral mass. However, information on ...
Physical heaviness of work and sitting at work as predictors of mortality : a 26-year follow-up of the Helsinki Birth Cohort Study Mikkola, Tuija M.; von Bonsdorff, Mikaela; Salonen, Minna K.; Kautiainen, Hannu; Ala-Mursula, Leena; Solovieva, Svetlana; Viikari-Juntura, Eira; Eriksson, Johan G. (BMJ Publishing Group, 2019)Objectives: To examine the relationships of late-career physical heaviness of work and sitting at work with mortality. A national-level job exposure matrix was used to determine the occupation-specific level of ...
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Body composition as a predictor of physical performance in older age : A ten-year follow-up of the Helsinki Birth Cohort Study Mikkola, Tuija M.; von Bonsdorff, Mikaela; Salonen, Minna K.; Simonen, Mika; Pohjolainen, Pertti; Osmond, Clive; Perälä, Mia-Maria; Rantanen, Taina; Kajantie, Eero; Eriksson, Johan G. (Elsevier Ireland Ltd., 2018)Background This study assessed how different measures of body composition predict physical performance ten years later among older adults. Methods The participants were 1076 men and women aged 57 to 70 years. Body ...
Association of childhood adversities and home atmosphere with functioning in old age : the Helsinki birth cohort study von Bonsdorff, Mikaela; Kokko, Katja; Salonen, Minna; von Bonsdorff, Monika; Poranen-Clark, Taina; Alastalo, Hanna; Kajantie, Eero; Osmond, Clive; Eriksson, Johan G. (Oxford University Press, 2019)Objective childhood adversities have been linked with adverse health outcomes, but less is known about the long-term consequences of childhood home atmosphere. We investigated whether childhood adversities and home ...