Proteomic insights into mental health status : plasma markers in young adults
Afonin, A. M., Piironen, A.-K., de Sousa, M. I., Ivanova, M., Alatalo, A., Whipp, A. M., Pulkkinen, L., Rose, R. J., van Kamp, I., Kaprio, J., & Kanninen, K. M. (2024). Proteomic insights into mental health status : plasma markers in young adults. Translational Psychiatry, 14, Article 55. https://doi.org/10.1038/s41398-024-02751-z
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2024Copyright
© The Author(s) 2024
Global emphasis on enhancing prevention and treatment strategies necessitates an increased understanding of the biological mechanisms of psychopathology. Plasma proteomics is a powerful tool that has been applied in the context of specific mental disorders for biomarker identification. The p-factor, also known as the “general psychopathology factor”, is a concept in psychopathology suggesting that there is a common underlying factor that contributes to the development of various forms of mental disorders. It has been proposed that the p-factor can be used to understand the overall mental health status of an individual. Here, we aimed to discover plasma proteins associated with the p-factor in 775 young adults in the FinnTwin12 cohort. Using liquid chromatography–tandem mass spectrometry, 13 proteins with a significant connection with the p-factor were identified, 8 of which were linked to epidermal growth factor receptor (EGFR) signaling. This exploratory study provides new insight into biological alterations associated with mental health status in young adults.
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Nature Publishing GroupISSN Search the Publication Forum
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https://converis.jyu.fi/converis/portal/detail/Publication/202812762
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This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 874724. Equal-Life is part of the European Human Exposome Network. Phenotype and omics data collection in FinnTwin12 cohort has been supported by FP7-HEALTH-F4-2007, grant agreement number 201413, National Institute of Alcohol Abuse and Alcoholism (grants AA-12502, AA-00145, and AA09203 to R J Rose; AA15416 and K02AA018755 to D M Dick; R01AA015416 to Jessica Salvatore) and the Academy of Finland (grants 100499, 205585, 118555, 141054, 264146, 308248 to JK, and the Centre of Excellence in Complex Disease Genetics (grants 312073, 336823, and 352792 to J Kaprio). J Kaprio acknowledges support from the Academy of Finland (grants 265240, 263278) and the Sigrid Juselius Foundation.![showless](/themes/JYX2//images/showless.png)
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