Corrected whole blood biomarkers : the equation of Dill and Costill revisited
Matomäki, P., Kainulainen, H., & Kyröläinen, H. (2018). Corrected whole blood biomarkers : the equation of Dill and Costill revisited. Physiological Reports, 6(12), Article e13749. https://doi.org/10.14814/phy2.13749
Julkaistu sarjassa
Physiological ReportsPäivämäärä
2018Tekijänoikeudet
© 2018 The Authors
An exercise bout or a dehydration often causes a reduction in plasma volume,
which should be acknowledged when considering the change in biomarkers
before and after the plasma changing event. The classic equation from Dill
and Costill (1974, J. Appl. Physiol., 37, 247–248) for plasma volume shift is
usually utilized in such a case. Although this works well with plasma and
serum biomarkers, we argue in this note that this traditional approach gives
misleading results in the context of whole blood biomarkers, such as lactate,
white cells, and thrombocytes. In this study, we demonstrate that to calculate
the change in the total amount of circulating whole blood biomarker, one
should utilize a formula BMpost
BMpre
Hbpre
Hbpost
1:
Here Hb and BM are, respectively, the concentrations for the hemoglobin and
for the inspected whole blood biomarker before (pre) and after (post) the
plasma changing incident.
Julkaisija
Wiley Periodicals; American Physiological Society; Physiological SocietyISSN Hae Julkaisufoorumista
2051-817XAsiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/28135725
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [2919]
Lisenssi
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Toxicity of biomining effluents to Daphnia magna : Acute toxicity and transcriptomic biomarkers
Sivula, Leena; Vehniäinen, Eeva-Riikka; Karjalainen, Anna; Kukkonen, Jussi (Pergamon Press, 2018)Increasing metal consumption is driving the introduction of new techniques such as biomining to exploit low grade ores. The biomining impacts notably aquatic ecosystems, yet, the applicability of ecotoxicological tests to ... -
Accelerometer-assessed sedentary work, leisure time and cardio-metabolic biomarkers during one year : Effectiveness of a cluster randomized controlled trial in parents with a sedentary occupation and young children
Pesola, Arto; Laukkanen, Arto; Heikkinen, Risto; Sipilä, Sarianna; Sääkslahti, Arja; Finni Juutinen, Taija (Public Library of Science, 2017)Background It is unknown whether reducing sedentary time at work and during leisure time is possible and effective during one year. Methods Office workers with young children were recruited for this one-year ... -
Lynchin syndrooma, elämäntavat ja biomarkkerit
Laakkonen, Eija; Seppälä, Toni; Mecklin, Jukka-Pekka (University of Jyväskylä, 2024)The study, Lynch Syndrome, lifestyle habits and biomarkers, investigates lifestyle habits (physical activity and nutrition) and blood-based biomarkers to understand their associations with cancer risk. The study includes ... -
Cross-sectional associations between cardiorespiratory fitness and NMR-derived metabolic biomarkers in children : the PANIC study
Haapala, Eero A.; Leppänen, Marja H.; Lehti, Maarit; Lintu, Niina; Tompuri, Tuomo; Viitasalo, Anna; Schwab, Ursula; Lakka, Timo A. (Frontiers Media SA, 2022)Objective: Cardiorespiratory fitness has been inversely associated with cardiovascular risk across the lifespan. Some studies in adults suggest that higher cardiorespiratory fitness is associated with cardioprotective ... -
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
McCartney, Daniel L.; Min, Josine L.; Richmond, Rebecca C.; Lu, Ake T.; Sobczyk, Maria K.; Davies, Gail; Broer, Linda; Guo, Xiuqing; Jeong, Ayoung; Jung, Jeesun; Kasela, Silva; Katrinli, Seyma; Kuo, Pei-Lun; Matias-Garcia, Pamela R.; Mishra, Pashupati P.; Nygaard, Marianne; Palviainen, Teemu; Patki, Amit; Raffield, Laura M.; Ratliff, Scott M.; Richardson, Tom G.; Robinson, Oliver; Soerensen, Mette; Sun, Dianjianyi; Tsai, Pei-Chien; van der Zee, Matthijs D.; Walker, Rosie M.; Wang, Xiaochuan; Wang, Yunzhang; Xia, Rui; Xu, Zongli; Yao, Jie; Zhao, Wei; Correa, Adolfo; Boerwinkle, Eric; Dugué, Pierre-Antoine; Durda, Peter; Elliott, Hannah R.; Gieger, Christian; The Genetics of DNA Methylation Consortium; de Geus, Eco J. C.; Harris, Sarah E.; Hemani, Gibran; Imboden, Medea; Kähönen, Mika; Kardia, Sharon L. R.; Kresovich, Jacob K.; Li, Shengxu; Lunetta, Kathryn L.; Mangino, Massimo; Mason, Dan; McIntosh, Andrew M.; Mengel-From, Jonas; Moore, Ann Zenobia; Murabito, Joanne M.; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Ollikainen, Miina; Pankow, James S.; Pedersen, Nancy L.; Peters, Annette; Polidoro, Silvia; Porteous, David J.; Raitakari, Olli; Rich, Stephen S.; Sandler, Dale P.; Sillanpää, Elina; Smith, Alicia K.; Southey, Melissa C.; Strauch, Konstantin; Tiwari, Hemant; Tanaka, Toshiko; Tillin, Therese; Uitterlinden, Andre G.; Van Den Berg, David J.; van Dongen, Jenny; Wilson, James G.; Wright, John; Yet, Idil; Arnett, Donna; Bandinelli, Stefania; Bell, Jordana T.; Binder, Alexandra M.; Boomsma, Dorret I.; Chen, Wei; Christensen, Kaare; Conneely, Karen N.; Elliott, Paul; Ferrucci, Luigi; Fornage, Myriam; Hägg, Sara; Hayward, Caroline; Irvin, Marguerite; Kaprio, Jaakko; Lawlor, Deborah A.; Lehtimäki, Terho; Lohoff, Falk W.; Milani, Lili; Milne, Roger L.; Probst-Hensch, Nicole; Reiner, Alex P.; Ritz, Beate; Rotter, Jerome I.; Smith, Jennifer A.; Taylor, Jack A.; van Meurs, Joyce B. J.; Vineis, Paolo; Waldenberger, Melanie; Deary, Ian J.; Relton, Caroline L.; Horvath, Steve; Marioni, Riccardo E. (Biomed Central, 2021)Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.