Nuclear entry and egress of parvoviruses
Mattola, S., Aho, V., Bustamante‐Jaramillo, L. F., Pizzioli, E., Kann, M., & Vihinen‐Ranta, M. (2022). Nuclear entry and egress of parvoviruses. Molecular Microbiology, 118(4), 295-308. https://doi.org/10.1111/mmi.14974
Published inMolecular Microbiology
© 2022 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.
Parvoviruses are small non-enveloped single-stranded DNA viruses, which depend on host cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear localization sequence and a phospholipase A2 domain on the capsid surface, and escape into the cytosol, parvovirus capsids enter the nucleus. Due to the small capsid diameter of 18–26 nm, intact capsids can potentially pass into the nucleus through nuclear pore complexes (NPCs). This might be facilitated by active nuclear import, but capsids may also follow an alternative entry pathway that includes activation of mitotic factors and local transient disruption of the nuclear envelope. The nuclear entry is followed by currently undefined events of viral genome uncoating. After genome release, viral replication compartments are initiated and infection proceeds. Parvoviral genomes replicate during cellular S phase followed by nuclear capsid assembly during virus-induced S/G2 cell cycle arrest. Nuclear egress of capsids occurs upon nuclear envelope degradation during apoptosis and cell lysis. An alternative pathway for nuclear export has been described using active transport through the NPC mediated by the chromosome region maintenance 1 protein, CRM1, which is enhanced by phosphorylation of the N-terminal domain of VP2. However, other alternative but not yet uncharacterized nuclear export pathways cannot be excluded. ...
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Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF
Additional information about fundingThis work was financed by the Jane and Aatos Erkko Foundation (MVR), Academy of Finland under the award numbers 330896 (MVR), and the Graduate School of the University of Jyväskylä (SM).
Showing items with similar title or keywords.
Mäntylä, Elina (University of Jyväskylä, 2016)
Mattola, Salla; Mäntylä, Elina; Aho, Vesa; Salminen, Sami; Leclerc, Simon; Oittinen, Mikko; Salokas, Kari; Järvensivu, Jani; Hakanen, Satu; Ihalainen, Teemu O.; Viiri, Keijo; Vihinen-Ranta, Maija (Frontiers Media SA, 2022)The nuclear export factor CRM1-mediated pathway is known to be important for the nuclear egress of progeny parvovirus capsids in the host cells with virus-mediated cell cycle arrest at G2/M. However, it is still unclear ...
Nykky, Jonna (University of Jyväskylä, 2014)
Mattola, Salla; Hakanen, Satu; Salminen, Sami; Aho, Vesa; Mäntylä, Elina; Ihalainen, Teemu O.; Kann, Michael; Vihinen-Ranta, Maija (MDPI AG, 2021)Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear ...
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