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• Concepts to Reveal Parvovirus–Nucleus Interactions 

  Mattola, Salla; Hakanen, Satu; Salminen, Sami; Aho, Vesa; Mäntylä, Elina; Ihalainen, Teemu O.; Kann, Michael; Vihinen-Ranta, Maija (MDPI AG, 2021)

  Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear ...

• Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins 

  Mattola, Salla; Salokas, Kari; Aho, Vesa; Mäntylä, Elina; Salminen, Sami; Hakanen, Satu; Niskanen, Einari A.; Svirskaite, Julija; Ihalainen, Teemu O.; Airenne, Kari J.; Kaikkonen-Määttä, Minna; Parrish, Colin R.; Varjosalo, Markku; Vihinen-Ranta, Maija (Public Library of Science (PLoS), 2022)

  Autonomous parvoviruses encode at least two nonstructural proteins, NS1 and NS2. While NS1 is linked to important nuclear processes required for viral replication, much less is known about the role of NS2. Specifically, ...

• Nuclear entry and egress of parvoviruses 

  Mattola, Salla; Aho, Vesa; Bustamante‐Jaramillo, Luisa F.; Pizzioli, Edoardo; Kann, Michael; Vihinen‐Ranta, Maija (Wiley, 2022)

  Parvoviruses are small non-enveloped single-stranded DNA viruses, which depend on host cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear localization sequence and a phospholipase ...

• Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection 

  Xu, Man; Perdomo, Maria Fernanda; Mattola, Salla; Pyöriä, Lari; Toppinen, Mari; Qiu, Jianming; Vihinen-Ranta, Maija; Hedman, Klaus; Nokso-Koivisto, Johanna; Aaltonen, Leena-Maija; Söderlund-Venermo, Maria (American Society for Microbiology, 2021)

  Human bocavirus 1 (HBoV1), a nonenveloped single-stranded DNA parvovirus, causes mild to life-threatening respiratory tract infections, acute otitis media, and encephalitis in young children. HBoV1 often persists in ...

• Parvovirus B19V Nonstructural Protein NS1 Induces Double-Stranded Deoxyribonucleic Acid Autoantibodies and End-Organ Damage in Nonautoimmune Mice 

  Puttaraksa, Kanoktip; Pirttinen, Heidi; Karvonen, Kati; Nykky, Jonna; Naides, Stanley J.; Gilbert, Leona (Oxford University Press, 2019)

  Background Viral infection is implicated in development of autoimmunity. Parvovirus B19 (B19V) nonstructural protein, NS1, a helicase, covalently modifies self double-stranded deoxyribonucleic acid (dsDNA) and induces ...