Concepts to Reveal Parvovirus–Nucleus Interactions
Mattola, S., Hakanen, S., Salminen, S., Aho, V., Mäntylä, E., Ihalainen, T. O., Kann, M., & Vihinen-Ranta, M. (2021). Concepts to Reveal Parvovirus–Nucleus Interactions. Viruses, 13(7), Article 1306. https://doi.org/10.3390/v13071306
© 2021 the Authors
Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear entry of incoming capsids and culminates in the successful passage of progeny capsids out of the nucleus. In this review, we will present past, current, and future microscopy and biochemical techniques and demonstrate their potential in revealing the dynamics and molecular interactions in the intranuclear processes of parvovirus infection. In particular, a number of advanced techniques will be presented for the detection of infection-induced changes, such as DNA modification and damage, as well as protein–chromatin interactions.
ISSN Search the Publication Forum1999-4915
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Related funder(s)Jane and Aatos Erkko Foundation; Academy of Finland
Funding program(s)Foundation; Academy Project, AoF
Additional information about fundingThis research was funded by the Jane and Aatos Erkko Foundation (M.V.-R.), Academy of Finland, grant numbers n330896 (M.V.-R.), 308315 (T.O.I.), 314106 (T.O.I.), and 332615 (E.M.); the Biocenter Finland, viral gene transfer (M.V.-R.); the Graduate School of the University of Jyvaskyla (S.M.); and a starting grant of the University of Gothenburg (M.K.).
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