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dc.contributor.authorKujala, Urho M.
dc.contributor.authorLeskinen, Tuija
dc.contributor.authorRottensteiner, Mirva
dc.contributor.authorAaltonen, Sari
dc.contributor.authorAla‐Korpela, Mika
dc.contributor.authorWaller, Katja
dc.contributor.authorKaprio, Jaakko
dc.date.accessioned2022-08-18T08:47:24Z
dc.date.available2022-08-18T08:47:24Z
dc.date.issued2022
dc.identifier.citationKujala, U. M., Leskinen, T., Rottensteiner, M., Aaltonen, S., Ala‐Korpela, M., Waller, K., & Kaprio, J. (2022). Physical activity and health : Findings from Finnish monozygotic twin pairs discordant for physical activity. <i>Scandinavian Journal of Medicine and Science in Sports</i>, <i>32</i>(9), 1316-1323. <a href="https://doi.org/10.1111/sms.14205" target="_blank">https://doi.org/10.1111/sms.14205</a>
dc.identifier.otherCONVID_148890570
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/82689
dc.description.abstractGenetic and early environmental differences including early health habits associate with future health. To provide insight on the causal nature of these associations, monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. Twin pairs discordant for leisure-time physical activity (LTPA) in early adult life are thus a powerful study design to investigate the associations between long-term LTPA and indicators of health and wellbeing. We have identified 17 LTPA discordant twin pairs from two Finnish twin cohorts and summarize key findings of these studies in this paper. The carefully characterized rare long-term LTPA discordant MZ twin pairs have participated in multi-dimensional clinical examinations. Key findings highlight that, compared to less active twins in such MZ twin pairs, the twins with higher long-term LTPA have higher physical fitness, reduced body fat, reduced visceral fat, reduced liver fat, increased lumen diameters of conduit arteries to the lower limbs, increased bone mineral density in loaded bone areas and an increased number of large high-density lipoprotein particles. The findings increase our understanding on the possible site-specific and system-level effects of long-term LTPA.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesScandinavian Journal of Medicine and Science in Sports
dc.rightsCC BY-NC 4.0
dc.titlePhysical activity and health : Findings from Finnish monozygotic twin pairs discordant for physical activity
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202208184229
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_dcae04bc
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1316-1323
dc.relation.issn0905-7188
dc.relation.numberinseries9
dc.relation.volume32
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumberOKM/39/626/2015
dc.subject.ysokaksostutkimus
dc.subject.ysoterveyskäyttäytyminen
dc.subject.ysoterveys
dc.subject.ysoliikunta
dc.subject.ysohyvinvointi (terveydellinen)
dc.subject.ysoelintavat
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysoperimä
dc.subject.ysokaksoset
dc.subject.ysorasvaprosentti
dc.subject.ysoliikuntatottumukset
dc.subject.ysogeenit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p18525
jyx.subject.urihttp://www.yso.fi/onto/yso/p11100
jyx.subject.urihttp://www.yso.fi/onto/yso/p2762
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
jyx.subject.urihttp://www.yso.fi/onto/yso/p22036
jyx.subject.urihttp://www.yso.fi/onto/yso/p5530
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p8862
jyx.subject.urihttp://www.yso.fi/onto/yso/p9845
jyx.subject.urihttp://www.yso.fi/onto/yso/p25528
jyx.subject.urihttp://www.yso.fi/onto/yso/p27403
jyx.subject.urihttp://www.yso.fi/onto/yso/p147
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1111/sms.14205
dc.relation.funderMinistry of Education and Cultureen
dc.relation.funderOpetus- ja kulttuuriministeriöfi
jyx.fundingprogramOthersen
jyx.fundingprogramMuutfi
jyx.fundinginformationTWINACTIVE study: The Finnish Ministry of Education and Culture (grant to UMK), Academy of Finland (grant to UMK), Finnish Cultural Foundation (grant to TL), Juho Vainio Foundation (grants to UMK, TL and SA) and Yrjö Jahnnsson Foundation (grant to SA). FITFATTWIN study: The Finnish Ministry of Education and Culture (UMK), META-PREDICT (within the European Union Seventh Framework Program, HEALTH-F2-2012-277936 to UMK), Juho Vainio Foundation (MR), and Finnish Cultural Foundation (MR). MOBILETWIN study: The Finnish Ministry of Education and Culture (grant OKM/56/626/2013 to UMK). The Finnish Twin Cohort Study has been supported by multiple grants over the past 45 years, including grants from the Academy of Finland (to JK) and NIH (to JK and Richard J Rose for FinnTwin16). The current grant (# 336823) from the Academy of Finland supporting JK is specifically acknowledged. MAK is supported by a research grant from the Sigrid Juselius Foundation, Finland.
dc.type.okmA2


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