Näytä suppeat kuvailutiedot

dc.contributor.authorJuppi, Hanna‐Kaarina
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorFachada, Vasco
dc.contributor.authorHyvärinen, Matti
dc.contributor.authorCronin, Neil
dc.contributor.authorAukee, Pauliina
dc.contributor.authorKarppinen, Jari E.
dc.contributor.authorSelänne, Harri
dc.contributor.authorKujala, Urho M.
dc.contributor.authorKovanen, Vuokko
dc.contributor.authorKarvinen, Sira
dc.contributor.authorLaakkonen, Eija K.
dc.date.accessioned2022-05-18T04:45:45Z
dc.date.available2022-05-18T04:45:45Z
dc.date.issued2022
dc.identifier.citationJuppi, H., Sipilä, S., Fachada, V., Hyvärinen, M., Cronin, N., Aukee, P., Karppinen, J. E., Selänne, H., Kujala, U. M., Kovanen, V., Karvinen, S., & Laakkonen, E. K. (2022). Total and regional body adiposity increases during menopause : evidence from a follow‐up study. <i>Aging Cell</i>, <i>21</i>(6), Article e13621. <a href="https://doi.org/10.1111/acel.13621" target="_blank">https://doi.org/10.1111/acel.13621</a>
dc.identifier.otherCONVID_144288991
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/81116
dc.description.abstractFor women, menopausal transition is a time of significant hormonal changes, which may contribute to altered body composition and regional adipose tissue accumulation. Excess adiposity, and especially adipose tissue accumulation in the central body region, increases women's risk of cardiovascular and metabolic conditions and affects physical functioning. We investigated the associations between menopausal progression and total and regional body adiposity measured with dual-energy X-ray absorptiometry and computed tomography in two longitudinal cohort studies of women aged 47–55 (n = 230 and 148, mean follow-up times 1.3 ± 0.7 and 3.9 ± 0.2 years, mean baseline BMI 25.5 kg/m2). We also examined associations between menopausal progression and skeletal muscle fiber characteristics, as well as adipose tissue-derived adipokines. Relative increases of 2%–14% were observed in regional and total body adiposity measures, with a pronounced fat mass increase in the android area (4% and 14% during short- and long-term follow-ups). Muscle fiber oxidative and glycolytic capacities and intracellular adiposity were not affected by menopause, but were differentially correlated with total and regional body adiposity at different menopausal stages. Menopausal progression and regional adipose tissue masses were positively associated with serum adiponectin and leptin, and negatively associated with resistin levels. Higher diet quality and physical activity level were also inversely associated with several body adiposity measures. Therefore, healthy lifestyle habits before and during menopause might delay the onset of severe metabolic conditions in women.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofseriesAging Cell
dc.rightsCC BY 4.0
dc.subject.otheradipokine
dc.subject.otherbody fat distribution
dc.subject.otherlongitudinal studies
dc.subject.otherobesity
dc.subject.otherperimenopause
dc.subject.otherphysical activity
dc.titleTotal and regional body adiposity increases during menopause : evidence from a follow‐up study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202205182751
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineBiomechanicsen
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1474-9718
dc.relation.numberinseries6
dc.relation.volume21
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber335249
dc.relation.grantnumber275323
dc.relation.grantnumber314181
dc.relation.grantnumber309504
dc.subject.ysolihavuus
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysopitkittäistutkimus
dc.subject.ysovaihdevuodet
dc.subject.ysorasvakudokset
dc.subject.ysonaiset
dc.subject.ysoikääntyminen
dc.subject.ysokehonkoostumus
dc.subject.ysolihakset
dc.subject.ysoseurantatutkimus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p823
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p14610
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
jyx.subject.urihttp://www.yso.fi/onto/yso/p24382
jyx.subject.urihttp://www.yso.fi/onto/yso/p16991
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p26989
jyx.subject.urihttp://www.yso.fi/onto/yso/p2784
jyx.subject.urihttp://www.yso.fi/onto/yso/p13719
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1111/acel.13621
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundinginformationAcademy of Finland, Grant/Award Number: 275323, 309504, 314181 and 335249
datacite.isSupplementedBy.doi10.17011/jyx/dataset/83491
datacite.isSupplementedByLaakkonen, Eija; Kovanen, Vuokko; Sipilä, Sarianna. (2022). <i>Data from Estrogenic Regulation of Muscle Apoptosis (ERMA) study</i>. University of Jyväskylä. <a href="https://doi.org/10.17011/jyx/dataset/83491" target="_blank">https://doi.org/10.17011/jyx/dataset/83491</a>. <a href="http://urn.fi/URN:NBN:fi:jyu-202210074820">https://urn.fi/URN:NBN:fi:jyu-202210074820</a>
dc.type.okmA1


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