Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women
Juppi, H.-K., Sipilä, S., Cronin, J. N., Karvinen, S., Karppinen, E. J., Tammelin, H. T., Aukee, P., Kovanen, V., Kujala, M. U., & Laakkonen, K. E. (2020). Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women. Journal of Clinical Medicine, 9(5), Article 1588. https://doi.org/10.3390/jcm9051588
Published inJournal of Clinical Medicine
DisciplineLiikuntafysiologiaBiomekaniikkaGerontologia ja kansanterveysLiikuntalääketiedeGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöExercise PhysiologyBiomechanicsGerontology and Public HealthSports and Exercise MedicineGerontology Research CenterSchool of Wellbeing
© 2020 the Authors
In midlife, women experience hormonal changes due to menopausal transition. A decrease especially in estradiol has been hypothesized to cause loss of muscle mass. This study investigated the effect of menopausal transition on changes in lean and muscle mass, from the total body to the muscle fiber level, among 47–55-year-old women. Data were used from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, where 234 women were followed from perimenopause to early postmenopause. Hormone levels (estradiol and follicle stimulating hormone), total and regional body composition (dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) scans), physical activity level (self-reported and accelerometer-measured) and muscle fiber properties (muscle biopsy) were assessed at baseline and at early postmenopause. Significant decreases were seen in lean body mass (LBM), lean body mass index (LBMI), appendicular lean mass (ALM), appendicular lean mass index (ALMI), leg lean mass and thigh muscle cross-sectional area (CSA). Menopausal status was a significant predictor for all tested muscle mass variables, while physical activity was an additional significant contributor for LBM, ALM, ALMI, leg lean mass and relative muscle CSA. Menopausal transition was associated with loss of muscle mass at multiple anatomical levels, while physical activity was beneficial for the maintenance of skeletal muscle mass. ...
Dataset(s) related to the publicationLaakkonen, Eija; Kovanen, Vuokko; Sipilä, Sarianna. (2022). Data from Estrogenic Regulation of Muscle Apoptosis (ERMA) study. University of Jyväskylä. https://doi.org/10.17011/jyx/dataset/83491. https://urn.fi/URN:NBN:fi:jyu-202210074820
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- Liikuntatieteiden tiedekunta 
Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF; Research costs of Academy Research Fellow, AoF; Academy Research Fellow, AoF
Additional information about fundingThis research was funded by the Academy of Finland (Vuokko Kovanen: grant 275323, Eija Laakkonen: grants 309504 and 314181).
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Juppi, Hanna‐Kaarina; Sipilä, Sarianna; Fachada, Vasco; Hyvärinen, Matti; Cronin, Neil; Aukee, Pauliina; Karppinen, Jari E.; Selänne, Harri; Kujala, Urho M.; Kovanen, Vuokko; Karvinen, Sira; Laakkonen, Eija K. (Wiley-Blackwell, 2022)For women, menopausal transition is a time of significant hormonal changes, which may contribute to altered body composition and regional adipose tissue accumulation. Excess adiposity, and especially adipose tissue ...
Girls with low motor competence may be particularly at risk of insufficient skeletal loading; latent profiles analysis of a four-year follow-up of Finnish adolescents Rantalainen, Timo; Gråsten, Arto; Haapala, Eero A.; Ortega, Francisco B.; Huhtiniemi, Mikko; Jaakkola, Timo (Oxford University Press (OUP), 2023)Purpose Adequate skeletal loads during the adolescent growth spurt are elemental in building a robust skeleton. Adolescents with poorer motor competence are less active and develop a less robust skeleton compared to their ...
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Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women : cross-sectional and longitudinal evidence Karvinen, Sira; Jergenson, Matthew J.; Hyvärinen, Matti; Aukee, Pauliina; Tammelin, Tuija; Sipilä, Sarianna; Kovanen, Vuokko; Kujala, Urho M.; Laakkonen, Eija K. (Frontiers Media, 2019)Cardiovascular disease (CVD) is the primary cause of mortality in women in developed countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that occurs after the onset of menopause. This ...
Menopausal symptoms and cardiometabolic risk factors in middle-aged women : A cross-sectional and longitudinal study with 4-year follow-up Hyvärinen, Matti; Karvanen, Juha; Juppi, Hanna-Kaarina; Karppinen, Jari E.; Tammelin, Tuija H.; Kovanen, Vuokko; Aukee, Pauliina; Sipilä, Sarianna; Rantalainen, Timo; Laakkonen, Eija K. (Elsevier BV, 2023)Objective To study associations of menopausal symptoms with cardiometabolic risk factors. Study design A cross-sectional and longitudinal study of a representative population sample of 1393 women aged 47–55 years with ...