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dc.contributor.authorZhuang, Haihui
dc.contributor.authorKarvinen, Sira
dc.contributor.authorTörmäkangas, Timo
dc.contributor.authorZhang, Xiaobo
dc.contributor.authorOjanen, Xiaowei
dc.contributor.authorVelagapudi, Vidya
dc.contributor.authorAlen, Markku
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorKainulainen, Heikki
dc.contributor.authorCheng, Sulin
dc.contributor.authorWiklund, Petri
dc.date.accessioned2021-06-08T10:36:21Z
dc.date.available2021-06-08T10:36:21Z
dc.date.issued2021
dc.identifier.citationZhuang, H., Karvinen, S., Törmäkangas, T., Zhang, X., Ojanen, X., Velagapudi, V., Alen, M., Britton, S. L., Koch, L. G., Kainulainen, H., Cheng, S., & Wiklund, P. (2021). Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue. <i>GeroScience</i>, <i>43</i>(6), 2679-2691. <a href="https://doi.org/10.1007/s11357-021-00387-1" target="_blank">https://doi.org/10.1007/s11357-021-00387-1</a>
dc.identifier.otherCONVID_96686414
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/76347
dc.description.abstractAerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, aging, and their interaction on metabolism, we utilized rat models selectively bred for low and high intrinsic aerobic capacity (LCRs/HCRs) and compared the metabolomics of serum, muscle, and white adipose tissue (WAT) at two time points: Young rats were sacrificed at 9 months of age, and old rats were sacrificed at 21 months of age. Targeted and semi-quantitative metabolomics analysis was performed on the ultra-pressure liquid chromatography tandem mass spectrometry (UPLC-MS) platform. The effects of aerobic capacity, aging, and their interaction were studied via regression analysis. Our results showed that high aerobic capacity is associated with an accumulation of isovalerylcarnitine in muscle and serum at rest, which is likely due to more efficient leucine catabolism in muscle. With aging, several amino acids were downregulated in muscle, indicating more efficient amino acid metabolism, whereas in WAT less efficient amino acid metabolism and decreased mitochondrial β-oxidation were observed. Our results further revealed that high aerobic capacity and aging interactively affect lipid metabolism in muscle and WAT, possibly combating unfavorable aging-related changes in whole body metabolism. Our results highlight the significant role of WAT metabolism for healthy aging.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesGeroScience
dc.rightsCC BY 4.0
dc.subject.otheraerobic capacity
dc.subject.otheraging
dc.subject.othermetabolomics
dc.subject.othermetabolites
dc.titleInteractive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202106083561
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineExercise Physiologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2679-2691
dc.relation.issn2509-2715
dc.relation.numberinseries6
dc.relation.volume43
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber298875
dc.subject.ysoaineenvaihdunta
dc.subject.ysokoe-eläinmallit
dc.subject.ysoaerobinen suorituskyky
dc.subject.ysoaineenvaihduntatuotteet
dc.subject.ysoikääntyminen
dc.subject.ysorasva-aineenvaihdunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p28104
jyx.subject.urihttp://www.yso.fi/onto/yso/p24946
jyx.subject.urihttp://www.yso.fi/onto/yso/p24583
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p38464
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s11357-021-00387-1
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationOpen access funding provided by University of Jyväskylä (JYU). This study was funded by the Academy of Finland (grant no. 298875 to HK), Biocenter Finland, and HILIFE (VV). Finnish Government Scholarship Pool - academic year 2019/2020 (ZH), EVO research grants (years 2014/2015) from Oulu University Hospital (MA), Shanghai Jiao Tong University 111 Project (B17029, SC), Shanghai Jiao Tong University Zhiyuan Foundation (grant CP2014013, SC), and China Postdoc Scholarship Council (201806230001, XO). The LCR and HCR rat models are funded by the Office of Infrastructure Programs grant P40ODO21331 (to L.G.K and S.L.B) from the National Institutes of Health. These rat models for low and high intrinsic exercise capacity are maintained as an international resource with support from the Department of Physiology & Pharmacology, The University of Toledo College of Medicine, Toledo, OH. Contact L.G.K Lauren.Koch2@UToledo.edu or S.L.B brittons@umich.edu for information on the rat models.


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