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dc.contributor.authorWikgren, Jan
dc.contributor.authorNokia, Miriam S.
dc.contributor.authorMäkinen, Elina
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKainulainen, Heikki
dc.contributor.authorLensu, Sanna
dc.date.accessioned2021-04-19T11:25:54Z
dc.date.available2021-04-19T11:25:54Z
dc.date.issued2021
dc.identifier.citationWikgren, J., Nokia, M. S., Mäkinen, E., Koch, L. G., Britton, S. L., Kainulainen, H., & Lensu, S. (2021). Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young. <i>Physiology and Behavior</i>, <i>236</i>, Article 113417. <a href="https://doi.org/10.1016/j.physbeh.2021.113417" target="_blank">https://doi.org/10.1016/j.physbeh.2021.113417</a>
dc.identifier.otherCONVID_66361224
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/75118
dc.description.abstractMetabolic syndrome (MetS) is a known risk factor for cognitive decline. Using polygenic rat models selectively bred for high and low intrinsic exercise capacity and simultaneously modelling as low and high innate risk factor for MetS respectively, we have previously shown that adult animals with lower exercise capacity/higher MetS risk perform poorly in tasks requiring flexible cognition. However, it is not known whether these deficits in cognition are present already at young age. Also, it is unclear whether the high risk genome is related also to lower-level cognition, such as sensory gating measured as prepulse inhibition. In this study, young and adult (5-8 weeks and ∼9 months) rats selectively bred for 36 generations as High-Capacity Runners (HCR) or Low-Capacity Runners (LCR) were tested for behavior in an open field task, modulation of startle reflex, and spatial learning in a T-maze. HCR rats were more active in the open field than LCR rats independent of age. Responses to the startle stimulus habituated to the same extent in LCR compared to HCR rats when young, but as adults, stronger habituation was seen in the HCR animals. The prepulse inhibition of startle response was equally strong in young HCR and LCR animals but the effect was shorter lasting in HCR animals. In T-maze, adult HCR animals unexpectedly showed attenuated learning, but we interpret this finding to stem from differences in motivation rather than learning ability. Overall, in the LCR rats with the risk genome for poor aerobic fitness and MetS, indications of compromised cognitive function are present already at a young age.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesPhysiology and Behavior
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherexercise capacity
dc.subject.otherstartle
dc.subject.otherpre-pulse inhibition
dc.subject.otheropen field
dc.subject.otherspatial learning
dc.subject.otherrat
dc.titleRats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202104192421
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn0031-9384
dc.relation.volume236
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 The Author(s). Published by Elsevier Inc.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber274098
dc.relation.grantnumber275954
dc.subject.ysometabolinen oireyhtymä
dc.subject.ysokognitiiviset taidot
dc.subject.ysorotta (laji)
dc.subject.ysooppimiskyky
dc.subject.ysoperinnöllinen alttius
dc.subject.ysokoe-eläinmallit
dc.subject.ysosuorituskyky
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p6238
jyx.subject.urihttp://www.yso.fi/onto/yso/p24920
jyx.subject.urihttp://www.yso.fi/onto/yso/p25843
jyx.subject.urihttp://www.yso.fi/onto/yso/p11792
jyx.subject.urihttp://www.yso.fi/onto/yso/p24980
jyx.subject.urihttp://www.yso.fi/onto/yso/p28104
jyx.subject.urihttp://www.yso.fi/onto/yso/p14041
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.physbeh.2021.113417
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiaohjelma, SAfi
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramAcademy Programme, AoFen
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationThis work was supported by the Academy of Finland (grant number 274098 to HK, 137783 and 275954 to MSN). The LCR and HCR rat models are maintained as an international resource with support from the NIH (P40OD021331R24OD010950 to LGK and SLB) and the Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH


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