Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus
Mäkinen, E., Lensu, S., Honkanen, M., Laitinen, P., Wikgren, J., Koch, L. G., Britton, S. L., Kainulainen, H., Pekkala, S., & Nokia, M. S. (2021). Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus. Brain Behavior and Immunity, 97, 250-259. https://doi.org/10.1016/j.bbi.2021.06.017
Julkaistu sarjassa
Brain Behavior and ImmunityTekijät
Päivämäärä
2021Oppiaine
PsykologiaLiikuntafysiologiaMonitieteinen aivotutkimuskeskusLiikuntalääketiedeHyvinvoinnin tutkimuksen yhteisöKäyttäytymisen muutos, hyvinvointi ja terveys elämänkulussaAivojen muutokset elinkaaren aikanaPsychologyExercise PhysiologyCentre for Interdisciplinary Brain ResearchSports and Exercise MedicineSchool of WellbeingBehaviour change, health, and well-being across the lifespanBrain changes across the life-spanTekijänoikeudet
© 2021 The Author(s). Published by Elsevier Inc.
BACKGROUND
Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high intrinsic aerobic capacity in order to test the association between low physical fitness, a genetic predisposition for obesity, and brain health. We hypothesized that low-capacity runner (LCR) rats with concurrently greater levels of adiposity would have increased hippocampal inflammation and reduced plasticity compared to the more physically fit high-capacity runner (HCR) rats.
METHODS
We examined markers for inflammation and brain plasticity in the hippocampi of LCR rats and compared them to HCR rats. The effect of age was determined by studying the rats at a young age (8 weeks) and later in life (40 weeks). We used western blots and immunohistochemistry to quantify the expression of target proteins.
RESULTS
Our study showed that the number of adult-born new neurons in the hippocampus was significantly lower in LCR rats than it was in HCR rats already at a young age and that the difference became more pronounced with age. The expression of synaptic proteins was higher in young animals relative to older ones. Brain inflammation tended to be higher in LCR rats than it was in the HCR rats, and more prominent in older rats than in young ones.
CONCLUSION
Our study is the first to demonstrate that low intrinsic aerobic fitness that is associated with obesity and poor metabolic health is also linked with reduced hippocampal structural plasticity at a young age. Our results also suggest that inflammation of the brain could be one factor mediating the link between obesity and poor cognitive performance.
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Julkaisija
Elsevier BVISSN Hae Julkaisufoorumista
0889-1591Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/98904004
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Rahoittaja(t)
Suomen Akatemia; Jenny ja Antti Wihurin rahastoRahoitusohjelmat(t)
Akatemiatutkija, SA; Akatemiaohjelma, SA; SäätiöLisätietoja rahoituksesta
This study was funded by the Academy of Finland, grant no. 274098 to HK, grant no. 275954 to MSN and grand no. 308042 to SP. The LCR-HCR rat model system was funded by National Institutes of Health Office of Research Infrastructure Programs Grant P40OD-021331 (to L. G. Koch and S. L. Britton). The Jenny and Antti Wihuri Foundation and the Central Finland Regional Fund of the Finnish Cultural Foundation are acknowledged for their personal grants to S.L. ...Lisenssi
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