Show simple item record

dc.contributor.authorJyväkorpi, Satu K.
dc.contributor.authorUrtamo, Annele
dc.contributor.authorStrandberg, Arto Y.
dc.contributor.authorvon Bonsdorff, Mikaela
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorKivimäki, Mika
dc.contributor.authorLuotola, Kari
dc.contributor.authorStrandberg, Timo E.
dc.date.accessioned2021-03-10T06:26:30Z
dc.date.available2021-03-10T06:26:30Z
dc.date.issued2020
dc.identifier.citationJyväkorpi, S. K., Urtamo, A., Strandberg, A. Y., von Bonsdorff, M., Salomaa, V., Kivimäki, M., Luotola, K., & Strandberg, T. E. (2020). Associations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study. <i>Clinical Nutrition</i>, <i>39</i>(5), 1491-1496. <a href="https://doi.org/10.1016/j.clnu.2019.06.011" target="_blank">https://doi.org/10.1016/j.clnu.2019.06.011</a>
dc.identifier.otherCONVID_31249016
dc.identifier.otherTUTKAID_81792
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/74558
dc.description.abstractBackground & aims Prognostic significance of metabolically healthy overweight and obesity (MHO) is under debate. However the relationship between MHO and health-related quality of life (HRQoL) is less studied. We compared successful aging (longevity plus HRQoL) in men with MHO, metabolically healthy normal weight (MHN) and metabolically unhealthy overweight and obesity (MUO). Methods In the Helsinki Businessmen Study longitudinal cohort, consisting of men born 1919 to 1934. In 1985/86, overweight (BMI≥25 kg/m2) and metabolic health were determined in 1309 men (median age 60 years). HRQoL was assessed using RAND-36/SF-36 in 2000 and 2007, and all-cause mortality retrieved from registers up to 2018. The proportion of men reaching 90 years was also calculated. Results Of the men, 469 (35.8%), 538 (41.1%), 276 (21.1%), and 26 (2.0%) were MHN, MHO, MUO and MUN, respectively. During the 32-year follow-up, 72.3% men died. With MHN as reference, adjusted hazard ratio with all-cause mortality was 1.08 (95% confidence interval [CI] 0.93 to 1.27) for MHO, and 1.18 (95% CI 0.95 to 1.47) for MUO. During follow-up, 273 men reached 90 years. With MHN as reference, adjusted odds ratio for MHO was 0.82 (95% CI 0.59 to 1.14) and 0.62 (95% CI 0.41 to 0.95) for MUO. Men in MHN group scored generally highest in RAND-36 HRQoL subscales in 2000 and 2007, of those significantly better in Physical functioning, Role physical, Role emotional, Bodily Pain, and General health sub-scales compared to MHO group in 2000. Conclusions As compared to MHN, MHO in late midlife does not increase mortality, but impairs odds for successful aging.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofseriesClinical Nutrition
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherRAND-36
dc.subject.othernonagenarians
dc.subject.othersuccessful aging
dc.subject.othermetabolically healthy overweight and obesity
dc.subject.othermetabolically unhealthy overweight and obesity
dc.titleAssociations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202103101910
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1491-1496
dc.relation.issn0261-5614
dc.relation.numberinseries5
dc.relation.volume39
dc.type.versionacceptedVersion
dc.rights.copyright© 2020 Elsevier
dc.rights.accesslevelopenAccessfi
dc.subject.ysoelämänlaatu
dc.subject.ysoikääntyminen
dc.subject.ysoylipaino
dc.subject.ysoaineenvaihdunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p10759
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p826
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.clnu.2019.06.011
jyx.fundinginformationThis work was supported by Gustaf och Victoria Frimurarestiftelse, Sweden; VTR-funding of the Helsinki University Hospital (TYH 2014245; 2015211), Finland; the Academy of Finland (grant number 311492). In addition, SKJ is supported by Päivikki Ja Sakari Sohlberg Foundation, Finland; MK is supported by NordForsk, the UK Medical Research Council (R024227), United Kingdom and Helsinki Institute of Life Sciences. Finland; VS is supported by the Finnish Foundation for Cardiovascular Research. The sponsors had no role in the design or conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY-NC-ND 4.0
Except where otherwise noted, this item's license is described as CC BY-NC-ND 4.0