Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity
Olvera‐Rojas, M., Plaza‐Florido, A., Solis‐Urra, P., Osuna‐Prieto, F. J., & Ortega, F. B. (2024). Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity. Pediatric Obesity, Early View. https://doi.org/10.1111/ijpo.13155
Published in
Pediatric ObesityAuthors
Date
2024Copyright
© 2024 the Authors
Objective
Children with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological-related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association with metabolic syndrome markers.
Methods
In this cross-sectional study, we included 84 Caucasian children (39% girls), aged 10.1 ± 1.1 years, from the ActiveBrains project (NCT02295072). A ninety-two-protein targeted approach using Olink's® technology was used.
Results
We identified distinct concentrations of CD38, LAIR2, MANF and NRP2 proteins in MHO compared with MUO. Moreover, individual metabolic syndrome (MS) markers were linked to nine proteins (CD38, CPM, EDA2R, IL12, JAMB, KYNU, LAYN, MSR1 and SMOC2) in children with OW/OB. These proteins play crucial roles in diverse biological processes (e.g., angiogenesis, cholesterol transport, nicotinamide adenine dinucleotide (NAD+) catalysis and maintenance of blood–brain barrier) related to brain health.
Conclusion
Our proteomics study suggests that cardiometabolic health (represented by MHO/MUO or individual MS markers) is associated with the concentration in plasma of several proteins involved in brain health. Larger-scale studies are needed to contrast/confirm these findings, with CD38 standing out as a particularly noteworthy and robust discovery.
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Publisher
Wiley-BlackwellISSN Search the Publication Forum
2047-6302Keywords
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https://converis.jyu.fi/converis/portal/detail/Publication/233332613
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Additional information about funding
ANID/BECAS Chile, Grant/Award Number:72180543; European Regional Development Fund (ERDF) of the European Commission, Grant/Award Number: 667302; Spanish Ministry of Economy and Competitiveness, Grant/Award Numbers: DEP2013-47540,DEP2016-79512-R, DEP2017-91544-EXP;Andalusian Operational Programme supported with ERDF, Grant/Award Number: B-CTS-355-UGR18; EXERNET Research Network on Exercise and Health, Grant/Award Number:DEP2005-00046/ACTI; University of Granada, Plan Propio de Investigación, Visiting Scholargrants and Excellence actions: Units of Excellence; Unit of Excellence on Exercise, Nutrition and Health (UCEENS) and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidadesand the ERDF, Grant/Award Number:SOMM17/6107/UGR; Spanish Ministry of Science, Innovation and Universities, Grant/Award Number: FPU 22/02476; High Council of Sports, Grant/Award Number: 09/UPB/19 ...License
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