Body composition and changes in health-related quality of life in older age : a 10-year follow-up of the Helsinki Birth Cohort Study
Mikkola, T. M., Kautiainen, H., von Bonsdorff, M. B., Salonen, M. K., Wasenius, N., Kajantie, E., & Eriksson, J. G. (2020). Body composition and changes in health-related quality of life in older age : a 10-year follow-up of the Helsinki Birth Cohort Study. Quality of Life Research, 29(8), 2039-2050. https://doi.org/10.1007/s11136-020-02453-1
Published inQuality of Life Research
DisciplineGerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of Wellbeing
© 2020 the Authors
PURPOSE: Most studies examining the associations between body composition and health-related quality of life (HRQoL) in older age have been cross-sectional and analyzed only fat or lean mass. Hence, it is poorly known whether fat and lean mass are independently associated with subsequent changes in HRQoL. We investigated whether baseline lean and fat mass are associated with changes in HRQoL over a 10-year period in older adults. METHODS: We studied 1044 men and women from the Helsinki Birth Cohort Study (age 57-70 years at baseline). Bioelectrical impedance analysis was used to derive baseline fat mass index (FMI, fat mass/height2) and lean mass index (lean mass/height2), dichotomized at sex-specific medians. HRQoL was assessed using RAND 36-item Health Survey at baseline and follow-up 10 years later. RESULTS: When controlled for lean mass and adjusted for potential confounders, high baseline FMI was associated with a greater decline in general health (standardized regression coefficient [β] = - 0.13, p = 0.001), physical functioning (β = - 0.11, p = 0.002), role physical (β = - 0.13, p = 0.003), vitality (β = - 0.08, p = 0.027), role emotional (β = - 0.12, p = 0.007), and physical component score (β = - 0.14, p < 0.001). High baseline FMI was also associated with low HRQoL in all physical domains at baseline (β: from - 0.38 to - 0.10). Lean mass was not strongly associated with HRQoL at baseline or change in HRQoL. CONCLUSION: In older community-dwelling adults, higher fat mass is, independent of lean mass, associated with lower physical HRQoL and greater decline in HRQoL. Prevention of adiposity may contribute to preservation of a good quality of life in older age. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Additional information about fundingOpen access funding provided by University of Helsinki including Helsinki University Central Hospital. This work was supported by Emil Aaltonen Foundation; Finnish Foundation for Diabetes Research; Foundation for Pediatric Research, Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Sigrid Jusélius Foundation; Samfundet Folkhälsan; Finska Läkaresällskapet; Liv och Hälsa; European Commission within the 7th Framework Programme (DORIAN, Grant Agreement No. 278603); and European Union Horizon 2020 programme (LifeCycle Grant No. 733206, DYNAHEALTH Grant No. 633595 and RECAP Grant No. SC1-2016-RTD-733180). The Academy of Finland supported EK (Grant Nos. 127437, 129306, 130326, 134791, 263924 and 274794); and J.G.E. (Grant Nos. 129369, 129907, 135072, 129255, and 126775). ...
Showing items with similar title or keywords.
Body composition as a predictor of physical performance in older age : A ten-year follow-up of the Helsinki Birth Cohort Study Mikkola, Tuija M.; von Bonsdorff, Mikaela; Salonen, Minna K.; Simonen, Mika; Pohjolainen, Pertti; Osmond, Clive; Perälä, Mia-Maria; Rantanen, Taina; Kajantie, Eero; Eriksson, Johan G. (Elsevier Ireland Ltd., 2018)Background This study assessed how different measures of body composition predict physical performance ten years later among older adults. Methods The participants were 1076 men and women aged 57 to 70 years. Body ...
Change in physical activity and health-related quality of life in old age : a 10-year follow-up study Jantunen, Hanna; Wasenius, Niko; Salonen, Minna K.; Kautiainen, Hannu; von Bonsdorff, Mikaela; Kajantie, Eero; Eriksson, Johan G. (Wiley-Blackwell Publishing Ltd., 2019)The aim of the study was to examine the association between change in leisure‐time physical activity (LTPA) and change in health‐related quality of life (HRQoL) and symptoms of depression during a 10‐year follow‐up. This ...
Juppi, Hanna‐Kaarina; Sipilä, Sarianna; Fachada, Vasco; Hyvärinen, Matti; Cronin, Neil; Aukee, Pauliina; Karppinen, Jari E.; Selänne, Harri; Kujala, Urho M.; Kovanen, Vuokko; Karvinen, Sira; Laakkonen, Eija K. (Wiley-Blackwell, 2022)For women, menopausal transition is a time of significant hormonal changes, which may contribute to altered body composition and regional adipose tissue accumulation. Excess adiposity, and especially adipose tissue ...
Disability, Health-Related Quality of Life and Mortality in Lumbar Spine Fusion Patients : A 5-Year Follow-Up and Comparison With a Population Sample Toivonen, Leevi; Pekkanen, Liisa; Neva, Marko H.; Kautiainen, Hannu; Kyrölä, Kati; Marttinen, Ilkka; Häkkinen, Arja (SAGE Publications, 2022)Study Design: Prospective follow-up study. Objectives: We aimed to assess the effect of lumbar spine fusion (LSF) on disability, health-related quality of life and mortality in a 5-year follow-up, and to compare these ...
Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study : A Five-year Follow-up Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riika; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; Saarto, Tiina (International Institute of Anticancer Research, 2020)Background/Aim: As the number of breast cancer survivors is increasing, their long-term health-related quality of life (HRQoL)has become an important issue. The aim of the study is to follow up the HRQoL of breast cancer ...