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dc.contributor.authorOwen, Patrick J.
dc.contributor.authorHart, Nicolas H.
dc.contributor.authorLatella, Christopher
dc.contributor.authorHendy, Ashlee M.
dc.contributor.authorLamon, Séverine
dc.contributor.authorRantalainen, Timo
dc.date.accessioned2021-01-26T11:36:46Z
dc.date.available2021-01-26T11:36:46Z
dc.date.issued2021
dc.identifier.citationOwen, P. J., Hart, N. H., Latella, C., Hendy, A. M., Lamon, S., & Rantalainen, T. (2021). Identifying and Assessing Inter-Muscular Fat at the Distal Diaphyseal Femur Measured by Peripheral Quantitative Computed Tomography (pQCT). <i>Journal of Clinical Densitometry</i>, <i>24</i>(1), 106-111. <a href="https://doi.org/10.1016/j.jocd.2019.11.001" target="_blank">https://doi.org/10.1016/j.jocd.2019.11.001</a>
dc.identifier.otherCONVID_33742262
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/73816
dc.description.abstractINTRODUCTION Inter/intramuscular fat can be assessed with peripheral Quantitative Computed Tomography (pQCT) and is of interest as an indicator of ‘muscle quality’. Typical pQCT scan sites (forearm, lower leg) have a low amount of inter/intramuscular fat, however distal diaphyseal femur scan sites with conspicuous inter/intramuscular fat have been identified as potentially more prudent scan sites, even in healthy adolescents. However, current state of the art analysis methods require labour-intensive manual segmentation of the scan. The purpose of the present study was to evaluate the reliability of a novel open source automated enclosing convex polygon approach (source code https://github.com/tjrantal/pQCT, commit cec9bce) to quantify inter/intramuscular fat from femoral pQCT scans in healthy adults. METHODOLOGY The distal diaphyseal femur (25% of tibial length from the knee joint towards the hip) of twenty seven adults aged 18 to 50 years were scanned twice, one week apart, using pQCT. Subcutaneous fat, muscle, inter/intramuscular fat, and marrow areas, and corresponding densities were evaluated using a method we have reported previously, as well as the novel enclosing convex polygon method. RESULTS The session-to-session reliability of the assessments was fair to excellent using the previously reported method as indicated by intraclass correlation coefficient (ICC2,1) ranging from 0.45 to 1.00, while the novel method produced excellent reliability (ICC2,1 0.78 to 1.00). CONCLUSION Distal diaphyseal femur appears to be a potentially informative and prudent scan site for inter/intramuscular fat evaluation with pQCT.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherInternational Society for Clinical Densitometry; Elsevier Inc.
dc.relation.ispartofseriesJournal of Clinical Densitometry
dc.rightsCC BY-NC-ND 4.0
dc.subject.othersubcutaneous fat
dc.subject.othersoft tissue
dc.subject.otherconvex hull
dc.subject.otherconvex envelope
dc.subject.othermuscle
dc.subject.otherbone
dc.titleIdentifying and Assessing Inter-Muscular Fat at the Distal Diaphyseal Femur Measured by Peripheral Quantitative Computed Tomography (pQCT)
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202101261276
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineBiomechanicsen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange106-111
dc.relation.issn1094-6950
dc.relation.numberinseries1
dc.relation.volume24
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 The International Society for Clinical Densitometry.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber328818
dc.relation.grantnumber321336
dc.subject.ysopehmytkudokset
dc.subject.ysokehonkoostumus
dc.subject.ysorasvakudokset
dc.subject.ysoluusto
dc.subject.ysolihakset
dc.subject.ysokuvantaminen
dc.subject.ysotietokonetomografia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p24162
jyx.subject.urihttp://www.yso.fi/onto/yso/p26989
jyx.subject.urihttp://www.yso.fi/onto/yso/p24382
jyx.subject.urihttp://www.yso.fi/onto/yso/p7233
jyx.subject.urihttp://www.yso.fi/onto/yso/p2784
jyx.subject.urihttp://www.yso.fi/onto/yso/p3532
jyx.subject.urihttp://www.yso.fi/onto/yso/p20535
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.jocd.2019.11.001
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationNational Library of Medicine for recording the Visible Human Data Set, and granting access to the scans. The study was funded by a Deakin University Central Research Grant Scheme (CRGS) 2017 grant to AMH and SL. TR was an Academy Research Fellow during the preparation of this manuscript ( Academy of Finland grant numbers 321336 and 328818 ). NHH is supported by a Cancer Council of Western Australia Research Fellowship. The source code of the implementation used in the present study is available from github ( https://github.com/tjrantal/pQCT , commit cec9bce onwards).


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