Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients
Vehmanen, L., Sievänen, H., Kellokumpu-Lehtinen, P., Nikander, R., Huovinen, R., Ruohola, J., Penttinen, H. M., Utriainen, M., Tokola, K., Blomqvist, C., & Saarto, T. (2021). Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients. Osteoporosis International, 32(3), 473-482. https://doi.org/10.1007/s00198-020-05611-w
Published inOsteoporosis International
© The Author(s) 2020
Summary A 12-month exercise program reversibly prevented hip bone loss in premenopausal women with early breast cancer. The bone-protective effect was maintained for 2 years after the end of the program but was lost thereafter. Purpose Breast cancer survivors are at an increased risk for osteoporosis and fracture. This 5-year follow-up of a randomized impact exercise intervention trial evaluated the maintenance of training effects on bone among breast cancer patients. Methods Five hundred seventy-three early breast cancer patients aged 35–68 years and treated with adjuvant therapy were allocated into a 12-month exercise program or a control group. Four hundred forty-four patients (77%) were included in the 5-year analysis. The exercise intervention comprised weekly supervised step aerobics, circuit exercises, and home training. Areal bone mineral density (aBMD) was measured by dual-energy X-ray absorptiometry. Physical activity was estimated in metabolic equivalent (MET) hours per week and physical performance assessed by 2-km walking and figure-8 running tests. Results In premenopausal patients, the 12-month exercise program maintained femoral neck (FN) and total hip (TH) aBMD for 3 years, but the protective effect was lost thereafter. The mean FN aBMD change in the exercise and control groups was − 0.2% and − 1.5% 1 year, − 1.1% and − 2.1% 3 years and − 3.3% versus − 2.4% 5 years after the beginning of the intervention, respectively. Lumbar spine (LS) bone loss was not prevented in premenopausal women and no training effects on aBMD were seen in postmenopausal women. The main confounding element of the study was the unexpected rise in physical activity among patients in the control group. The physical performance improved among premenopausal women in the exercise group compared with the controls. Conclusion The 12-month exercise program prevented FN and TH bone loss in premenopausal breast cancer patients for 3 years. The bone-protective effect was reversible and lost thereafter. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Additional information about fundingOpen access funding provided by University of Helsinki including Helsinki University Central Hospital. The study has been financially supported by the Cancer Society of Finland, the Finnish Cancer Foundation, the Academy of Finland, the Comprehensive Cancer Center Helsinki University Central Hospital, the Social Insurance Institution of Finland, the Finnish Ministry of Education, Finska Läkaresällskapet, the Special Government Grant for Health Science Research, the Helander Foundation, the Paulo Foundation, Finnish Cultural Foundation, and Medical Fund of the Pirkanmaa Hospital District. Finnish Astra-Zeneca sponsored step benches for the study. The study was sponsored by The Finnish Breast Cancer group. ...
Showing items with similar title or keywords.
Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study : A Five-year Follow-up Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riika; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; Saarto, Tiina (International Institute of Anticancer Research, 2020)Background/Aim: As the number of breast cancer survivors is increasing, their long-term health-related quality of life (HRQoL)has become an important issue. The aim of the study is to follow up the HRQoL of breast cancer ...
Physiotherapy for the functioning of breast cancer patients : studies of the effectiveness of physiotherapy methods and exercise, of the content and timing of postoperative education and of the experienced functioning and disability Kärki, Anne (University of Jyväskylä, 2005)These studies were undertaken to create a broader understanding of the effectiveness of physiotherapy methods and exercise, and to evaluate the requirements, content and timing of physiotherapy services after breast cancer ...
Nikander, Riku (University of Jyväskylä, 2009)The objective of this dissertation was to determine the types of exercise loading that are associated with the strength of bones. Four cross-sectional studies were conducted between 2004 and 2008 including 378 athletes and ...
Waller, Katja (University of Jyväskylä, 2011)
Physical function and lean body mass as predictors of bone loss after hip fracture : a prospective follow-up study Suominen, Tuuli H.; Edgren, Johanna; Salpakoski, Anu; Kallinen, Mauri; Cervinka, Tomas; Rantalainen, Timo; Törmäkangas, Timo; Heinonen, Ari; Sipilä, Sarianna (BioMed Central, 2020)Background Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of bone density ...