Long-term effects of aromatase inhibitor withdrawal on bone mineral density in early breast cancer patients : 10-year follow-up results of the BREX study
Blomqvist, C., Vehmanen, L., Kellokumpu-Lehtinen, P.-L., Huovinen, R., Ruohola, J., Penttinen, H., Sievänen, H., Nikander, R., Utriainen, M., & Saarto, T. (2024). Long-term effects of aromatase inhibitor withdrawal on bone mineral density in early breast cancer patients : 10-year follow-up results of the BREX study. Breast Cancer Research and Treatment, Early online. https://doi.org/10.1007/s10549-024-07252-7
Julkaistu sarjassa
Breast Cancer Research and TreatmentTekijät
Päivämäärä
2024Tekijänoikeudet
© 2024 the Authors
Purpose
We aimed to provide long-term bone mineral density (BMD) data on early breast cancer patients of the BREX (Breast Cancer and Exercise) study. The effects of exercise and adjuvant endocrine treatment 10 years after randomization were analyzed, with special emphasis on aromatase inhibitor (AI) therapy discontinuation at 5 years.
Methods
The BREX study randomized 573 pre- and postmenopausal breast cancer patients into a 1-year supervised exercise program or a control group. 372 patients were included into the current follow-up analysis. BMD (g/cm2) was measured by dual-energy X-ray absorptiometry at lumbar spine (LS), left femoral neck (FN), and the total hip. Separate groups were displayed according to baseline menopausal status, and whether the patient had discontinued AI therapy at 5 years or not.
Results
The BMD change from 5 to 10 years did not significantly differ between the two randomized arms. AI discontinuation at 5 years had statistically significant BMD effects. The FN BMD continued to decrease in patients who discontinued AI therapy during the first 5-year off-treatment, but the decrease was three-fold less than in patients without AI withdrawal (− 1.4% v. − 3.8%). The LS BMD increased (+ 2.6%) in patients with AI withdrawal during the first 5 years following treatment discontinuation, while a BMD decrease (-1.3%) was seen in patients without AI withdrawal.
Conclusion
This study is to our knowledge the first to quantify the long-term impact of AI withdrawal on BMD. Bone loss associated with AI therapy seems partially reversible after stopping treatment. Trial registration: http://www.clinicaltrials.gov/ (Identifier Number NCT00639210).
...
Julkaisija
SpringerISSN Hae Julkaisufoorumista
0167-6806Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/207877257
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [3123]
Lisätietoja rahoituksesta
Open Access funding provided by University of Helsinki (including Helsinki University Central Hospital). This work was supported by Cancer Society of Finland, Finnish Cancer Foundation, Academy of Finland, Comprehensive Cancer Center of Helsinki University Central Hospital, Social Insurance Institution of Finland, Finnish Ministry of Education, Finska Läkaresällskapet, Special Government Grant for Health Science Research (Finland), Helander Foundation, Paulo Foundation, Finnish Cultural Foundation, Medical Fund of the Pirkanmaa Hospital District, and Finnish Breast Cancer group. Astra Zeneca (FI) sponsored step benches for the study. ...Lisenssi
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients
Vehmanen, L.; Sievänen, H.; Kellokumpu-Lehtinen, P.; Nikander, R.; Huovinen, R.; Ruohola, J.; Penttinen, H. M.; Utriainen, M.; Tokola, K.; Blomqvist, C.; Saarto, T. (Springer, 2021)Summary A 12-month exercise program reversibly prevented hip bone loss in premenopausal women with early breast cancer. The bone-protective effect was maintained for 2 years after the end of the program but was lost ... -
Effect of Combining Impact-Aerobic and Strength Exercise, and Dietary Habits on Body Composition in Breast Cancer Survivors Treated with Aromatase Inhibitors
Garcia-Unciti, Marisol; Palacios Samper, Natalia; Méndez-Sandoval, Sofía; Idoate, Fernando; Ibáñez-Santos, Javier (MDPI AG, 2023)This study examines both the effect of a twice-weekly combined exercise—1 h session of strength and 1 h session of impact-aerobic—on body composition and dietary habits after one year of treatment with aromatase inhibitors ... -
Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study
Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riikka; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; Hakamies-Blomqvist, Liisa; Saarto, Tiina (Elsevier, 2021)Objective To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise ... -
Factors predicting long-term physical activity of breast cancer survivors. 5-year-follow-up of the BREX exercise intervention study
Kokkonen, Kristiina; Kellokumpu-Lehtinen, Pirkko-Liisa; Kankaanpää, Markku; Nikander, Riku; Penttinen, Heidi Maria; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riikka; Kautiainen, Hannu; Blomqvist, Carl; Saarto, Tiina (Informa UK Limited, 2022)Background The benefits of exercise training are well documented among breast cancer (BC) survivors. Patients decrease their physical activity during treatment, and many fail to regain their previous exercise levels. There ... -
Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study : A Five-year Follow-up
Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riika; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; Saarto, Tiina (International Institute of Anticancer Research, 2020)Background/Aim: As the number of breast cancer survivors is increasing, their long-term health-related quality of life (HRQoL)has become an important issue. The aim of the study is to follow up the HRQoL of breast cancer ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.