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dc.contributor.authorVehmanen, L.
dc.contributor.authorSievänen, H.
dc.contributor.authorKellokumpu-Lehtinen, P.
dc.contributor.authorNikander, R.
dc.contributor.authorHuovinen, R.
dc.contributor.authorRuohola, J.
dc.contributor.authorPenttinen, H. M.
dc.contributor.authorUtriainen, M.
dc.contributor.authorTokola, K.
dc.contributor.authorBlomqvist, C.
dc.contributor.authorSaarto, T.
dc.date.accessioned2020-09-07T06:47:38Z
dc.date.available2020-09-07T06:47:38Z
dc.date.issued2021
dc.identifier.citationVehmanen, L., Sievänen, H., Kellokumpu-Lehtinen, P., Nikander, R., Huovinen, R., Ruohola, J., Penttinen, H. M., Utriainen, M., Tokola, K., Blomqvist, C., & Saarto, T. (2021). Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients. <i>Osteoporosis International</i>, <i>32</i>(3), 473-482. <a href="https://doi.org/10.1007/s00198-020-05611-w" target="_blank">https://doi.org/10.1007/s00198-020-05611-w</a>
dc.identifier.otherCONVID_41932424
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/71658
dc.description.abstractSummary A 12-month exercise program reversibly prevented hip bone loss in premenopausal women with early breast cancer. The bone-protective effect was maintained for 2 years after the end of the program but was lost thereafter. Purpose Breast cancer survivors are at an increased risk for osteoporosis and fracture. This 5-year follow-up of a randomized impact exercise intervention trial evaluated the maintenance of training effects on bone among breast cancer patients. Methods Five hundred seventy-three early breast cancer patients aged 35–68 years and treated with adjuvant therapy were allocated into a 12-month exercise program or a control group. Four hundred forty-four patients (77%) were included in the 5-year analysis. The exercise intervention comprised weekly supervised step aerobics, circuit exercises, and home training. Areal bone mineral density (aBMD) was measured by dual-energy X-ray absorptiometry. Physical activity was estimated in metabolic equivalent (MET) hours per week and physical performance assessed by 2-km walking and figure-8 running tests. Results In premenopausal patients, the 12-month exercise program maintained femoral neck (FN) and total hip (TH) aBMD for 3 years, but the protective effect was lost thereafter. The mean FN aBMD change in the exercise and control groups was − 0.2% and − 1.5% 1 year, − 1.1% and − 2.1% 3 years and − 3.3% versus − 2.4% 5 years after the beginning of the intervention, respectively. Lumbar spine (LS) bone loss was not prevented in premenopausal women and no training effects on aBMD were seen in postmenopausal women. The main confounding element of the study was the unexpected rise in physical activity among patients in the control group. The physical performance improved among premenopausal women in the exercise group compared with the controls. Conclusion The 12-month exercise program prevented FN and TH bone loss in premenopausal breast cancer patients for 3 years. The bone-protective effect was reversible and lost thereafter.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesOsteoporosis International
dc.rightsCC BY-NC 4.0
dc.subject.otherbone density
dc.subject.otherbreast cancer
dc.subject.otherweight-bearing impact aerobic exercise
dc.subject.othertraining
dc.subject.otherosteoporosis
dc.subject.otherphysical activity
dc.titleFive-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202009075767
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange473-482
dc.relation.issn0937-941X
dc.relation.numberinseries3
dc.relation.volume32
dc.type.versionacceptedVersion
dc.rights.copyright© The Author(s) 2020
dc.rights.accesslevelopenAccessfi
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysoaerobinen harjoittelu
dc.subject.ysoharjoittelu
dc.subject.ysorintasyöpä
dc.subject.ysoliikunta
dc.subject.ysoosteoporoosi
dc.subject.ysoluuntiheys
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p24767
jyx.subject.urihttp://www.yso.fi/onto/yso/p26412
jyx.subject.urihttp://www.yso.fi/onto/yso/p20019
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
jyx.subject.urihttp://www.yso.fi/onto/yso/p10781
jyx.subject.urihttp://www.yso.fi/onto/yso/p22879
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1007/s00198-020-05611-w
jyx.fundinginformationOpen access funding provided by University of Helsinki including Helsinki University Central Hospital. The study has been financially supported by the Cancer Society of Finland, the Finnish Cancer Foundation, the Academy of Finland, the Comprehensive Cancer Center Helsinki University Central Hospital, the Social Insurance Institution of Finland, the Finnish Ministry of Education, Finska Läkaresällskapet, the Special Government Grant for Health Science Research, the Helander Foundation, the Paulo Foundation, Finnish Cultural Foundation, and Medical Fund of the Pirkanmaa Hospital District. Finnish Astra-Zeneca sponsored step benches for the study. The study was sponsored by The Finnish Breast Cancer group.


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