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dc.contributor.authorJuppi, Hanna-Kaarina
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorCronin, J. Neil
dc.contributor.authorKarvinen, Sira
dc.contributor.authorKarppinen, E. Jari
dc.contributor.authorTammelin, H. Tuija
dc.contributor.authorAukee, Pauliina
dc.contributor.authorKovanen, Vuokko
dc.contributor.authorKujala, M. Urho
dc.contributor.authorLaakkonen, K. Eija
dc.date.accessioned2020-05-27T11:26:02Z
dc.date.available2020-05-27T11:26:02Z
dc.date.issued2020
dc.identifier.citationJuppi, H.-K., Sipilä, S., Cronin, J. N., Karvinen, S., Karppinen, E. J., Tammelin, H. T., Aukee, P., Kovanen, V., Kujala, M. U., & Laakkonen, K. E. (2020). Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women. <i>Journal of Clinical Medicine</i>, <i>9</i>(5), Article 1588. <a href="https://doi.org/10.3390/jcm9051588" target="_blank">https://doi.org/10.3390/jcm9051588</a>
dc.identifier.otherCONVID_35745361
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/69265
dc.description.abstractIn midlife, women experience hormonal changes due to menopausal transition. A decrease especially in estradiol has been hypothesized to cause loss of muscle mass. This study investigated the effect of menopausal transition on changes in lean and muscle mass, from the total body to the muscle fiber level, among 47–55-year-old women. Data were used from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, where 234 women were followed from perimenopause to early postmenopause. Hormone levels (estradiol and follicle stimulating hormone), total and regional body composition (dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) scans), physical activity level (self-reported and accelerometer-measured) and muscle fiber properties (muscle biopsy) were assessed at baseline and at early postmenopause. Significant decreases were seen in lean body mass (LBM), lean body mass index (LBMI), appendicular lean mass (ALM), appendicular lean mass index (ALMI), leg lean mass and thigh muscle cross-sectional area (CSA). Menopausal status was a significant predictor for all tested muscle mass variables, while physical activity was an additional significant contributor for LBM, ALM, ALMI, leg lean mass and relative muscle CSA. Menopausal transition was associated with loss of muscle mass at multiple anatomical levels, while physical activity was beneficial for the maintenance of skeletal muscle mass.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesJournal of Clinical Medicine
dc.rightsCC BY 4.0
dc.subject.othermenopause
dc.subject.otherfemale aging
dc.subject.otherskeletal muscle
dc.subject.othersarcopenia
dc.subject.otherestradiol
dc.subject.otherphysical activity
dc.titleRole of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass : A Follow-Up Study in Middle-Aged Finnish Women
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202005273518
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineBiomechanicsen
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2077-0383
dc.relation.numberinseries5
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber275323
dc.relation.grantnumber314181
dc.relation.grantnumber309504
dc.subject.ysoliikunta
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysotuki- ja liikuntaelimet
dc.subject.ysoestradioli
dc.subject.ysovaihdevuodet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p2785
jyx.subject.urihttp://www.yso.fi/onto/yso/p19425
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/jcm9051588
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundinginformationThis research was funded by the Academy of Finland (Vuokko Kovanen: grant 275323, Eija Laakkonen: grants 309504 and 314181).
datacite.isSupplementedBy.doi10.17011/jyx/dataset/83491
datacite.isSupplementedByLaakkonen, Eija; Kovanen, Vuokko; Sipilä, Sarianna. (2022). <i>Data from Estrogenic Regulation of Muscle Apoptosis (ERMA) study</i>. University of Jyväskylä. <a href="https://doi.org/10.17011/jyx/dataset/83491" target="_blank">https://doi.org/10.17011/jyx/dataset/83491</a>. <a href="http://urn.fi/URN:NBN:fi:jyu-202210074820">https://urn.fi/URN:NBN:fi:jyu-202210074820</a>
dc.type.okmA1


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