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dc.contributor.authorWang, Xiaoyu
dc.contributor.authorGuo, Yongkun
dc.contributor.authorZhang, Yunge
dc.contributor.authorLi, Jinju
dc.contributor.authorGao, Zhongqi
dc.contributor.authorLi, Yingxin
dc.contributor.authorZhou, Tianlin
dc.contributor.authorZhang, Hui
dc.contributor.authorHe, Jianghong
dc.contributor.authorCong, Fengyu
dc.date.accessioned2020-05-20T11:19:55Z
dc.date.available2020-05-20T11:19:55Z
dc.date.issued2020
dc.identifier.citationWang, Xiaoyu; Guo, Yongkun; Zhang, Yunge; Li, Jinju; Gao, Zhongqi; Li, Yingxin; Zhou, Tianlin; Zhang, Hui; He, Jianghong; Cong, Fengyu (2020). Combined Behavioral and Mismatch Negativity Evidence for the Effects of Long-Lasting High-Definition tDCS in Disorders of Consciousness : A Pilot Study. Frontiers in Neuroscience, 14, 381. DOI: 10.3389/fnins.2020.00381
dc.identifier.otherCONVID_35693645
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/69108
dc.description.abstractObjective: To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs). Methods: We employed a with-in group repeated measures design with an anode HD-tDCS protocol (2 mA, 20 min, the precuneus) on 11 (2 vegetative state and nine minimally conscious state) patients with DOCs. MMN and Coma Recovery Scale-Revised (CRS-R) scores were measured at four time points: before the treatment of HD-tDCS (T0), after a single session of HD-tDCS (T1), after the treatment of 7 days (T2) and 14 days (T3). A frequency-deviant oddball paradigm with two deviation magnitudes (standard stimulus: 1000 Hz, small deviant stimuli: 1050 Hz, large deviant stimuli: 1200 Hz) was adopted to elicit MMN. Results: Significant improvements of CRS-R score were found after 7-day (T2) and 14-day (T3) treatment compared with baseline (T0). Regarding the MMN, significant improvements of MMN amplitudes were observed after a single session of stimulation (T1), 7-day (T2) and 14-day treatment (T3) compared with baseline (T0). Additionally, there were significant negative correlations between CRS-R scores and MMN amplitudes elicited by both large and small deviant stimuli. Conclusion: Long-term HD-tDCS over precuneus might improve signs of consciousness in patients with DOCs as measured by CRS-R total scores, and MMN could be an assistant assessment in the course of tDCS treatment.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Neuroscience
dc.rightsCC BY 4.0
dc.subject.otherhigh-definition transcranial direct current stimulation
dc.subject.otherdisorder of consciousness
dc.subject.othercoma recovery scale-revised
dc.subject.othermismatch negativity
dc.subject.otherevent-related potentials
dc.titleCombined Behavioral and Mismatch Negativity Evidence for the Effects of Long-Lasting High-Definition tDCS in Disorders of Consciousness : A Pilot Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202005203361
dc.contributor.laitosInformaatioteknologian tiedekuntafi
dc.contributor.laitosFaculty of Information Technologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1662-4548
dc.relation.volume14
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 Wang, Guo, Zhang, Li, Gao, Li, Zhou, Zhang, He and Cong
dc.rights.accesslevelopenAccessfi
dc.subject.ysokooma
dc.subject.ysotajunnan taso
dc.subject.ysostimulointi
dc.subject.ysopoikkeavuusnegatiivisuus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p28310
jyx.subject.urihttp://www.yso.fi/onto/yso/p28926
jyx.subject.urihttp://www.yso.fi/onto/yso/p20809
jyx.subject.urihttp://www.yso.fi/onto/yso/p26013
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fnins.2020.00381
jyx.fundinginformationThis research was supported by National Natural Science Foundation of China (Grant No. 91748105), the Fundamental Research Funds for the Central Universities [DUT2019] in Dalian University of Technology in China, the Key Scientific Research Projects of Henan Province Universities and Colleges (19A320041), and the Medicine and Health Science and Technology Project of Zhejiang Province (2019RC254).


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