Show simple item record

dc.contributor.authorQiu, Yue
dc.contributor.authorLin, Qiu-Hua
dc.contributor.authorKuang, Li-Dan
dc.contributor.authorGong, Xiao-Feng
dc.contributor.authorCong, Fengyu
dc.contributor.authorWang, Yu-Ping
dc.contributor.authorCalhoun, Vince D.
dc.date.accessioned2020-01-14T13:12:12Z
dc.date.available2020-02-27T22:35:29Z
dc.date.issued2019
dc.identifier.citationQiu, Y., Lin, Q.-H., Kuang, L.-D., Gong, X.-F., Cong, F., Wang, Y.-P., & Calhoun, V. D. (2019). Spatial source phase : A new feature for identifying spatial differences based on complex-valued resting-state fMRI data. <i>Human Brain Mapping</i>, <i>40</i>(9), 2662-2676. <a href="https://doi.org/10.1002/hbm.24551" target="_blank">https://doi.org/10.1002/hbm.24551</a>
dc.identifier.otherCONVID_28949009
dc.identifier.otherTUTKAID_80833
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/67296
dc.description.abstractSpatial source phase, the phase information of spatial maps extracted from functional magnetic resonance imaging (fMRI) data by data‐driven methods such as independent component analysis (ICA), has rarely been studied. While the observed phase has been shown to convey unique brain information, the role of spatial source phase in representing the intrinsic activity of the brain is yet not clear. This study explores the spatial source phase for identifying spatial differences between patients with schizophrenia (SZs) and healthy controls (HCs) using complex‐valued resting‐state fMRI data from 82 individuals. ICA is first applied to preprocess fMRI data, and post‐ICA phase de‐ambiguity and denoising are then performed. The ability of spatial source phase to characterize spatial differences is examined by the homogeneity of variance test (voxel‐wise F‐test) with false discovery rate correction. Resampling techniques are performed to ensure that the observations are significant and reliable. We focus on two components of interest widely used in analyzing SZs, including the default mode network (DMN) and auditory cortex. Results show that the spatial source phase exhibits more significant variance changes and higher sensitivity to the spatial differences between SZs and HCs in the anterior areas of DMN and the left auditory cortex, compared to the magnitude of spatial activations. Our findings show that the spatial source phase can potentially serve as a new brain imaging biomarker and provide a novel perspective on differences in SZs compared to HCs, consistent with but extending previous work showing increased variability in patient data.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.relation.ispartofseriesHuman Brain Mapping
dc.rightsIn Copyright
dc.subject.otherauditory cortex
dc.subject.othercomplex-valued fMRI data
dc.subject.otherdefault mode network
dc.subject.otherresting-state fMRI data
dc.subject.otherspatial source phase
dc.titleSpatial source phase : A new feature for identifying spatial differences based on complex-valued resting-state fMRI data
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202001081075
dc.contributor.laitosInformaatioteknologian tiedekuntafi
dc.contributor.laitosFaculty of Information Technologyen
dc.contributor.oppiaineTietotekniikkafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineMathematical Information Technologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2020-01-08T07:15:16Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2662-2676
dc.relation.issn1065-9471
dc.relation.numberinseries9
dc.relation.volume40
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 Wiley Periodicals, Inc.
dc.rights.accesslevelopenAccessfi
dc.subject.ysotoiminnallinen magneettikuvaus
dc.subject.ysoaivotutkimus
dc.subject.ysoskitsofrenia
dc.subject.ysosignaalianalyysi
dc.subject.ysoriippumattomien komponenttien analyysi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p24211
jyx.subject.urihttp://www.yso.fi/onto/yso/p23705
jyx.subject.urihttp://www.yso.fi/onto/yso/p9659
jyx.subject.urihttp://www.yso.fi/onto/yso/p26805
jyx.subject.urihttp://www.yso.fi/onto/yso/p38529
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1002/hbm.24551
dc.type.okmA1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

In Copyright
Except where otherwise noted, this item's license is described as In Copyright