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dc.contributor.authorSarin, Heikki
dc.contributor.authorAhtiainen, Juha
dc.contributor.authorHulmi, Juha
dc.contributor.authorIhalainen, Johanna
dc.contributor.authorWalker, Simon
dc.contributor.authorSchildt, Maria
dc.contributor.authorPerola, Markus
dc.contributor.authorPeltonen, Heikki
dc.date.accessioned2019-10-10T11:18:19Z
dc.date.available2020-10-01T21:35:12Z
dc.date.issued2019
dc.identifier.citationSarin, H., Ahtiainen, J., Hulmi, J., Ihalainen, J., Walker, S., Schildt, M., Perola, M., & Peltonen, H. (2019). Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways. <i>Medicine and Science in Sports and Exercise</i>, <i>51</i>(9), 1866-1875. <a href="https://doi.org/10.1249/mss.0000000000002003" target="_blank">https://doi.org/10.1249/mss.0000000000002003</a>
dc.identifier.otherCONVID_30120596
dc.identifier.otherTUTKAID_81222
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65805
dc.description.abstractIntroduction: Arising evidence suggests that resistance training has the potential to induce beneficial modulation of biomarker profile. To date, however, only immediate responses to resistance training have been investigated using high-throughput metabolomics whereas the effects of chronic resistance training on biomarker profile have not been studied in detail. Methods: A total of 86 recreationally active healthy men without previous systematic resistance training background were allocated into i) a resistance training (RT) group (n=68, age 33 ± 7 years, body mass index (BMI) 28 ± 3 kg/m2 ) and ii) a non-RT group (n=18, age 31 ± 4 years, BMI 27 ± 3 kg/m2 ). Blood samples were collected at baseline (PRE), after 4 weeks (POST-4wk), and after 16 weeks of resistance training intervention (POST-16wk), as well as baseline and after the non-RT period (20‒24 weeks). Nuclear magnetic resonance (NMR) -metabolome platform was used to determine metabolomic responses to chronic resistance training. Results: Overall, the resistance training intervention resulted in favorable alterations (P < 0.05) in body composition with increased levels of lean mass (~2.8 %), decreased levels of android (~9.6 %), and total fat mass (~7.5 %). These changes in body composition were accompanied by anti-atherogenic alterations in serum metabolome profile (FDR < 0.05) as reductions in nonHDL cholesterol (e.g., free cholesterol, remnant cholesterol, IDL cholesterols, LDL cholesterols) and related apolipoprotein B, and increments in conjugated linoleic fatty acids levels were observed. Individuals with the poorest baseline status (i.e. body composition, metabolome profile) benefitted the most from the resistance training intervention. Conclusions: In conclusion, resistance training improves cardiometabolic risk factors and serum metabolome even in previously healthy young men. Thus, suggesting attenuated risk for future cardiovascular disease.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofseriesMedicine and Science in Sports and Exercise
dc.rightsIn Copyright
dc.subject.otherresistance exercise
dc.subject.otheromics
dc.subject.otherbiomarkers
dc.subject.othercardiovascular disease
dc.titleResistance Training Induces Antiatherogenic Effects on Metabolomic Pathways
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201910094374
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineValmennus- ja testausoppifi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineScience of Sport Coaching and Fitness Testingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-10-09T12:15:22Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1866-1875
dc.relation.issn0195-9131
dc.relation.numberinseries9
dc.relation.volume51
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 by the American College of Sports Medicine
dc.rights.accesslevelopenAccessfi
dc.subject.ysovoimaharjoittelu
dc.subject.ysorasva-arvot
dc.subject.ysomarkkerit
dc.subject.ysokuntoliikunta
dc.subject.ysokehonkoostumus
dc.subject.ysoaminohapot
dc.subject.ysolipidit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p16233
jyx.subject.urihttp://www.yso.fi/onto/yso/p25711
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p3708
jyx.subject.urihttp://www.yso.fi/onto/yso/p26989
jyx.subject.urihttp://www.yso.fi/onto/yso/p9530
jyx.subject.urihttp://www.yso.fi/onto/yso/p4799
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1249/mss.0000000000002003
jyx.fundinginformationThe study was funded by The Academy of Finland grant 269517 (M. P.), NovoNordisk Foundation grant NNF16OC0020866 (M. P.), Tekes-National Technology Agency of Finland with University of Jyväskylä (Decision 70007/13) (H. P.), Finnish Ministry of Education and Culture (2006) (M. K.-S.), Juho Vainion Foundation (H. V. S.), and Orion Pharma Foundation (H. V. S.). The authors of this article declare no competing interests and that the results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. The authors also state that results of the present study do not constitute endorsement by ACSM.


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