Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children
Haapala, E. A., Väistö, J., Ihalainen, J. K., Tomaselli González, C., Leppänen, M. H., Veijalainen, A., Sallinen, T., Eloranta, A.-M., Ekelund, U., Schwab, U., Brage, S., Atalay, M., & Lakka, T. A. (2022). Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children. European Journal of Sport Science, 22(6), 906-915. https://doi.org/10.1080/17461391.2021.1892830
Julkaistu sarjassaEuropean Journal of Sport Science
OppiaineLiikuntalääketiedeLiikuntafysiologiaBiomekaniikkaSports and Exercise MedicineExercise PhysiologyBiomechanics
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
We investigated the associations of physical activity (PA), sedentary time (ST), and diet quality with biomarkers of inflammation in 390 children (192 girls, 198 boys) aged 6-8 years. PA energy expenditure (PAEE), light PA, moderate PA (MPA), vigorous PA (VPA), moderate-to-vigorous PA (MVPA), and ST were assessed by combined movement and heart rate sensor. Finnish Children Healthy Eating Index was calculated using data from 4 d food records. Body fat percentage (BF%) was measured by dual-energy X-ray absorptiometry. High-sensitivity C-reactive protein (Hs-CRP), leptin, interleukin-6 (IL-6), adiponectin, tumour necrosis factor-α, and glycoprotein acetyls were measured from fasting blood samples. PAEE, MPA, VPA, and MVPA were inversely associated with hs-CRP (β=-191 to -139, 95% CI=-0.294 to -0.024), leptin (β=-0.409 to -0.301, 95% CI=-0.499 to -0.107), IL-6 (β=-0.136 to -0.104, 95% CI=-0.240 to -0.001) and PAEE, MPA, and MVPA were inversely associated with glycoprotein acetyls (β=-0.117 to -0.103, 95% CI=-0.213 to -0.001). ST was directly associated with hs-CRP (β=0.170, 95% CI=0.070 to 0.269), leptin (β=0.355, 95% CI=0.265 to 0.445), and IL-6 (β=0.105, 95% CI=0.005 to 0.205). VPA was inversely associated with hs-CRP, leptin, and IL-6 in children with higher BF% (β=-0.344 to -0.181, 95% CI=-0.477 to -0.033) but not among children with lower BF% (β=-0.007 to 0.033, 95% CI=-0.183 to 0.184). In conclusion, PA was inversely and ST directly associated with circulating levels of biomarkers of inflammation among children. Furthermore, we observed that PA was inversely associated with these biomarkers for inflammation in children with a higher BF%. ...
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Lisätietoja rahoituksestaThe PANIC Study has financially been supported by Ministry of Education and Culture of Finland, Ministry of Social Affairs and Health of Finland, Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Foundation for Paediatric Research, Diabetes Research Foundation in Finland, Finnish Foundation for Cardiovascular Research, Juho Vainio Foundation, Paavo Nurmi Foundation, Yrjö Jahnsson Foundation, and the city of Kuopio. Moreover, the PhD students and postdoctoral researchers of The PANIC Study have been supported by Program for Clinical Research and Program for Health Sciences of Doctoral School of University of Eastern Finland, Finnish Doctoral Programs in Public Health, Päivikki and Sakari Sohlberg Foundation, Paulo Foundation, Jalmari and Rauha Ahokas Foundation, Aarne and Aili Turunen Foundation, Finnish Medical Foundation, Jenny and Antti Wihuri Foundation, Kuopio Naturalists' Society, Olvi Foundation, and the city of Kuopio. SB was supported by UK Medical Research Council (MC_UU_12015/3) and the NIHR Biomedical Research Centre Cambridge [IS-BRC-1215-20014]. The sponsors had no role in designing the study, the collection, analysis, or interpretation of the data, the writing of the report, or the decision to submit the manuscript for publication. ...
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A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children : the PANIC study Lakka,Timo A.; Lintu, Niina; Väistö, Juuso; Viitasalo, Anna; Sallinen, Taisa; Haapala, Eero A.; Tompuri, Tuomo T.; Soininen, Sonja; Karjalainen, Panu; Schnurr, Theresia M.; Mikkonen, Santtu; Atalay, Mustafa; Kilpeläinen, Tuomas O.; Laitinen, Tomi; Laaksonen, David E.; Savonen, Kai; Brage, Soren; Schwab, Ursula; Jääskeläinen, Jarmo; Lindi, Virpi; Eloranta, Aino-Maija (Springer, 2020)Aims/hypothesis We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly ...
Associations of neck and shoulder pain with objectively measured physical activity and sedentary time among school-aged children Pirnes, Katariina Pauliina; Kallio, Jouni; Kankaanpää, Anna; Häkkinen, Arja; Tammelin, Tuija (Walter de Gruyter GmbH, 2020)Objectives The potential effects of physical activity and sedentary time on children’s increasing neck and shoulder pain are unclear. The aim of this cross-sectional study was to evaluate the associations between objectively ...
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Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children : the PANIC study Korhonen, Marika; Väistö, Juuso; Veijalainen, Aapo; Leppänen, Marja; Ekelund, Ulf; Laukkanen, Jari A.; Brage, Soren; Lintu, Niina; Haapala, Eero A.; Lakka, Timo A. (Routledge, Taylor & Francis, 2021)We investigated the longitudinal associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with arterial health among children. In our primary analyses, we investigated 245 children ...
An Overview on the Associations between Health Behaviors and Brain Health in Children and Adolescents with Special Reference to Diet Quality Naveed, Sehrish; Lakka, Timo; Haapala, Eero A. (MDPI, 2020)Unhealthy diet has been associated with overweight, obesity, increased cardiometabolic risk, and recently, to impaired cognition and academic performance. The aim of this review is to provide an overview of the associations ...