Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways
Sarin, H., Ahtiainen, J., Hulmi, J., Ihalainen, J., Walker, S., Schildt, M., Perola, M., & Peltonen, H. (2019). Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways. Medicine and Science in Sports and Exercise, 51(9), 1866-1875. https://doi.org/10.1249/mss.0000000000002003
Published inMedicine and Science in Sports and Exercise
DisciplineLiikuntafysiologiaValmennus- ja testausoppiExercise PhysiologyScience of Sport Coaching and Fitness Testing
© 2019 by the American College of Sports Medicine
Introduction: Arising evidence suggests that resistance training has the potential to induce beneficial modulation of biomarker profile. To date, however, only immediate responses to resistance training have been investigated using high-throughput metabolomics whereas the effects of chronic resistance training on biomarker profile have not been studied in detail. Methods: A total of 86 recreationally active healthy men without previous systematic resistance training background were allocated into i) a resistance training (RT) group (n=68, age 33 ± 7 years, body mass index (BMI) 28 ± 3 kg/m2 ) and ii) a non-RT group (n=18, age 31 ± 4 years, BMI 27 ± 3 kg/m2 ). Blood samples were collected at baseline (PRE), after 4 weeks (POST-4wk), and after 16 weeks of resistance training intervention (POST-16wk), as well as baseline and after the non-RT period (20‒24 weeks). Nuclear magnetic resonance (NMR) -metabolome platform was used to determine metabolomic responses to chronic resistance training. Results: Overall, the resistance training intervention resulted in favorable alterations (P < 0.05) in body composition with increased levels of lean mass (~2.8 %), decreased levels of android (~9.6 %), and total fat mass (~7.5 %). These changes in body composition were accompanied by anti-atherogenic alterations in serum metabolome profile (FDR < 0.05) as reductions in nonHDL cholesterol (e.g., free cholesterol, remnant cholesterol, IDL cholesterols, LDL cholesterols) and related apolipoprotein B, and increments in conjugated linoleic fatty acids levels were observed. Individuals with the poorest baseline status (i.e. body composition, metabolome profile) benefitted the most from the resistance training intervention. Conclusions: In conclusion, resistance training improves cardiometabolic risk factors and serum metabolome even in previously healthy young men. Thus, suggesting attenuated risk for future cardiovascular disease. ...
PublisherLippincott Williams & Wilkins
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- Liikuntatieteiden tiedekunta 
Additional information about fundingThe study was funded by The Academy of Finland grant 269517 (M. P.), NovoNordisk Foundation grant NNF16OC0020866 (M. P.), Tekes-National Technology Agency of Finland with University of Jyväskylä (Decision 70007/13) (H. P.), Finnish Ministry of Education and Culture (2006) (M. K.-S.), Juho Vainion Foundation (H. V. S.), and Orion Pharma Foundation (H. V. S.). The authors of this article declare no competing interests and that the results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. The authors also state that results of the present study do not constitute endorsement by ACSM. ...
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