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dc.contributor.authorÅström, Max J.
dc.contributor.authorvon Bonsdorff, Mikaela B.
dc.contributor.authorPerälä, Mia-Maria
dc.contributor.authorSalonen, Minna K.
dc.contributor.authorRantanen, Taina
dc.contributor.authorKajantie, Eero
dc.contributor.authorSimonen, Mika
dc.contributor.authorPohjolainen, Pertti
dc.contributor.authorHaapanen, Markus J.
dc.contributor.authorGuzzardi, Maria A.
dc.contributor.authorIozzo, Patricia
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorEriksson, Johan G.
dc.date.accessioned2019-09-20T08:53:38Z
dc.date.available2019-09-20T08:53:38Z
dc.date.issued2019
dc.identifier.citationÅström, M. J., von Bonsdorff, M. B., Perälä, M.-M., Salonen, M. K., Rantanen, T., Kajantie, E., Simonen, M., Pohjolainen, P., Haapanen, M. J., Guzzardi, M. A., Iozzo, P., Kautiainen, H., & Eriksson, J. G. (2019). Telomere length and physical performance among older people : the Helsinki Birth Cohort Study. <i>Mechanisms of Ageing and Development</i>, <i>183</i>, Article 111145. <a href="https://doi.org/10.1016/j.mad.2019.111145" target="_blank">https://doi.org/10.1016/j.mad.2019.111145</a>
dc.identifier.otherCONVID_32811544
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65583
dc.description.abstractTelomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the Helsinki Birth Cohort Study at two time-points; a baseline examination in 2001-2004 at a mean age of 61 years and a follow-up examination approximately 10 years later in 2011-2013. Telomere length was measured both at baseline and at follow-up using real-time quantitative polymerase chain reaction. Physical performance was evaluated only at follow-up using the Senior Fitness Test (SFT), which assesses strength, flexibility and endurance. In women, shorter telomere length at follow-up (p = 0.044) and greater telomere attrition during follow-up time (p = 0.022) were associated with poorer physical performance after adjusting for covariates (age at baseline, smoking status, body mass index at baseline, follow-up time and educational attainment). No similar associations were found for men. This indicates that, at least in women, telomere length could potentially be used as a biomarker for physical performance, however, more longitudinal studies are needed to confirm this association.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesMechanisms of Ageing and Development
dc.rightsCC BY-NC-ND 4.0
dc.subject.otheraging
dc.subject.otherbiomarkers
dc.subject.otherepidemiology
dc.subject.otherphysical function
dc.titleTelomere length and physical performance among older people : the Helsinki Birth Cohort Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909204230
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn0047-6374
dc.relation.volume183
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 Published by Elsevier B.V.
dc.rights.accesslevelopenAccessfi
dc.subject.ysofyysinen toimintakyky
dc.subject.ysotelomeerit
dc.subject.ysomarkkerit
dc.subject.ysofyysinen kunto
dc.subject.ysoikääntyminen
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p27172
jyx.subject.urihttp://www.yso.fi/onto/yso/p37745
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p7384
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.mad.2019.111145
jyx.fundinginformationThis work was supported by Emil Aaltonen Foundation; Finnish Foundation for Cardiovascular Research; Finnish Foundation for Diabetes Research; Finnish Foundation for Pediatric Research; Juho Vainio Foundation; Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Samfundet Folkhälsan; Finska Läkaresällskapet; Liv och Hälsa; European Commission FP7 DORIAN [grant number 278603]; EU H2020-PHC-2014-DynaHealth [grant number 633595]; and Academy of Finland [grant numbers 257239 to MBvB, 127437 to EK, 129306 to EK, 130326 to EK, 134791 to EK, 263924 to EK, 274794 to EK, 129369 to JGE, 129907 to JGE, 135072 to JGE, 129255 to JGE, 126775 to JGE].


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